ArticleJournal of cardiovascular translational research2019
Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model.
Article in Journal of cardiovascular translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The Past, Present, and Promising Future of Direct Cardiac Compression Devices.JACC. Basic to translational science · 2025Review
- Mechanoresponsive Drug Release from a Flexible, Tissue-Adherent, Hybrid Hydrogel Actuator.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Preclinical Proof-of-Concept of a Minimally Invasive Direct Cardiac Compression Device for Pediatric Heart Support.Cardiovascular engineering and technology · 2024Article
- Advances in novel devices for the treatment of heart failure.Heart failure reviews · 2023Review
- Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy.Journal of anatomy · 2023Review
- Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept.The Annals of thoracic surgery · 2022Article
- The CorInnova Implantable Cardiac Assist System for Direct Cardiac Compression.Reviews in cardiovascular medicine · 2022Review
- Support Pressure Acting on the Epicardial Surface of a Rat Left Ventricle-A Computational Study.Frontiers in cardiovascular medicine · 2022Article
- Restructuring the Heart From Failure to Success: Role of Structural Interventions in the Realm of Heart Failure.Frontiers in cardiovascular medicine · 2022Review
- On 3 legs shall we stand: Combined innovation for treatment of ischemic cardiomyopathy.JTCVS open · 2021Article
- Dynamic Augmentation of Left Ventricle and Mitral Valve Function With an Implantable Soft Robotic Device.JACC. Basic to translational science · 2020Article
- Magnetically Active Cardiac Patches as an Untethered, Non-Blood Contacting Ventricular Assist Device.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1.9 L/min. Heart assist with the device during failure state resulted in an average absolute increase in CO of 1.0 L/min, along with a decline in ventricular work to 67.5% of the total LV SW. Combined with repeated success of minimally invasive device implant, the resulting increases in cardiac hemodynamics achieved while still unloading the heart demonstrate the potential of the CorInnova device for temporary heart assist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.