Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats.

Pen-Li Lu, Meng-Li Tsai, Fu-Shan Jaw, Chen-Tung Yen

Abstract read

In one paragraph

Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Thalamic subnetworks as units of function.Nature neuroscience · 2022
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Authors and funding

4 authors.

Pen-Li LuInstitute of Biomedical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taibei, 10617, Taiwan.

Meng-Li TsaiDepartment of Biomechatronic Engineering, National Ilan University, 1, Sec. 1, Shen-Lung Road, I-Lan, 26047, Taiwan.

Fu-Shan JawInstitute of Biomedical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taibei, 10617, Taiwan.

Chen-Tung YenDepartment of Life Science, National Taiwan University, 1 Roosevelt Road, Section 4, Taibei, 10617, Taiwan. ctyen@ntu.edu.tw.ORCID http://orcid.org/0000-0002-0076-4487

Funding

National Health Research Institutes NHRI-EX101-10104NINational Science Council NSC100-2221-E-002-064National Science Council NSC100-2311-B-002-002-MY3National Science Council NSC 100-2923-E-002-007-MY3

6 · The paper itself

Abstract

Mediodorsal thalamic nucleus (MD) is a critical relay of nociception. This study recorded responses of MD neurons to noxious mechanical and thermal stimuli in isoflurane anesthetized rats. We found the threshold of noxious mechanical stimulation was 141 gw and that of noxious heat stimulation was 46 °C. A significantly higher percentage of noxious inhibitory neurons were found in the medial and central part of the MD, whereas a higher percentage of noxious excitatory neurons were found in the lateral part of the MD and adjacent intralaminar nuclei. The differential distribution of excitatory and inhibitory neurons implies functional differentiation between the medial and lateral part of the MD in nociception processing. Furthermore, by an analysis of the stimulus-response function (SRF), we found 80% of these excitatory neurons had a step-function or hat-shape-like SRF. This suggests that most of the MD neurons may serve as a system to distinguish innocuous versus noxious stimuli.

Indexed as

AnimalsMaleMediodorsal Thalamic NucleusNeuronsNociceptionNociceptorsRatsRats, WistarIntralaminar thalamic nucleiMediodorsal thalamic nucleusMultiple single-unit recordingStimulus–response function

Identifiers

PMID30604289

DOI10.1007/s12576-018-00656-3

PMCPMC10716950

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