Evidence map›Paper›PMID 30604178›Full record

ArticleEuropean journal of nutrition2020

Curcuma supplementation in high-fat-fed C57BL/6 mice: no beneficial effect on lipid and glucose profile or prevention of weight gain.

Caroline Bertoncini Silva, Priscila Giacomo Fassini, Leandra Náira Zambelli Ramalho, Edemilson Cardoso da Conceição, Aline José Coelho Moreira Zordan, Daniela Carlos, Vivian Marques Miguel Suen

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In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Caroline Bertoncini SilvaDivision of Nutrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil. bertoncinicaroline@gmail.com.ORCID http://orcid.org/0000-0002-5925-5353
Priscila Giacomo FassiniDivision of Nutrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Leandra Náira Zambelli RamalhoDepartament of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Edemilson Cardoso da ConceiçãoFaculty of Pharmacy of Federal University of Goiás, Rua 240, esquina com 5ª Avenida, s/n, Setor Leste Universitário, Goiânia, Goiás, CEP 74605-170, Brazil.
Aline José Coelho Moreira ZordanDivision of Nutrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Daniela CarlosDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Vivian Marques Miguel SuenDivision of Nutrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Universidade de São Paulo · BRUniversidade Federal de Goiás · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 134187/2015-6
6 · The paper itself

Abstract

purposeThis experimental study investigated the effects of curcuma supplementation on weight gain, Body Adiposity Index, glucose and lipid profile, and liver and pancreas histology in C57BL/6 mice fed with a high-fat diet.

methods40 animals were separated into four groups: standard diet (SD), standard diet plus curcuma (SD + C), high-fat diet (HFD), and high-fat diet plus curcuma (HFD + C). Curcuma dose was 8 mg/animal/day. Histological and biochemical analyses were performed at the end of the experimental period.

resultsCurcuma prevented weight gain, despite a higher food intake, and increased brown adipose tissue weight only in mice receiving standard diet. However, these changes were not observed in HFD + C group. The groups that received curcuma (SD + C and HFD + C) showed a pancreas with diffuse macro- and microgoticular steatosis.

conclusionsCurcuma supplementation did not prevent weight gain or improved glucose and lipid profile in mice receiving high-fat diet. Furthermore, there was evidence of possible curcuma toxicity in the pancreas of C57BL/6 mice. The implications of these findings on humans still need to be investigated.

Indexed as

Dietary SupplementsAnimalsCurcumaDiet, High-FatGlucoseLipid MetabolismMaleMiceMice, Inbred C57BLModels, AnimalWeight GainGlucoseC57BL/6 miceCurcumaPhytotherapyToxicityWeight gain

Identifiers

PMID30604178
OpenAlexW2907378752

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.