Observational studyJournal of general internal medicine2019
The Effect of Financial Conflict of Interest, Disclosure Status, and Relevance on Medical Research from the United States.
Observational study in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Academic Influence and Industry Funding in Platelet-Rich Plasma Injections: Coauthorship Network Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Pooled it
- Research Review: Conflicts of Interest (COIs) in autism early intervention research - a meta-analysis of COI influences on intervention effects.Journal of child psychology and psychiatry, and allied disciplines · 2021Pooled it
- Funding of evidence included within public comments submitted to inform Medicare national coverage determinations.Health affairs scholar · 2024Article
- Explaining the concepts and examples of conflict of interest and its management in the medical laboratory system of Iran: A scoping review.Journal of education and health promotion · 2024Article
- Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry.BMC medical ethics · 2023Article
- Evidence for stratified conflicts of interest policies in research contexts: a methodological review.BMJ open · 2022Review
- Awareness and perception of pharmacy researchers about conflict of interest: A study from the MENA region.Journal of applied pharmaceutical science · 2022Article
- Does conflict of interest affect the reported fusion rates of bone graft substitutes and extenders?North American Spine Society journal · 2022Review
- The influence of industry sponsorship and conflict of interest on results and conclusions of systematic reviews regarding treatment of knee osteoarthritis.Osteoarthritis and cartilage open · 2021Article
- Predictability in Contemporary Medicine.Frontiers in medicine · 2021Article
- A Content Analysis of Self-Reported Financial Relationships in Biomedical Research.AJOB empirical bioethicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFinancial interactions between industry and healthcare providers are reportable. Substantial discrepancies have been detected between industry and self-report of these conflicts of interest (COIs).
objectiveOur aim was to determine if authors who fail to disclose reportable COI are more likely to publish findings that are favorable to industry than authors with no COI.
designIn this blinded, observational study of medical and surgical primary research articles in PubMed, 590 articles were reviewed. MAIN MEASURES: Reportable financial relationships between authors and industry were evaluated. COIs were considered to have relevance if they were associated with the product(s) mentioned by an article. Primary outcome was favorability, defined as an impression favorable to the product(s) discussed by an article and determined by 3 independent, blinded clinicians for each article. Primary analysis compared Incomplete Self-Disclosure to No COI. Two-level multivariable mixed-effects ordered logistic regression was used to assess factors associated with favorability. KEY
resultsA 69% discordance rate existed between industry and self-report in COI disclosure. When authors failed to disclose COI, their conclusions were more likely to favor industry partners than authors without COI (favorable ratings 73% versus 62%, RR 1.18, p = < 0.001). On univariate (any COI 74% versus no COI 62%, RR 1.11, p = < 0.001) and multivariable analyses, any COI was associated with favorability.
conclusionsAll financial COIs (disclosed or undisclosed, relevant or not relevant, research or non-research) influence whether studies report findings favorable to industry sponsors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.