Observational studyJapanese journal of ophthalmology2019
Three cases of acute-onset bilateral photophobia.
Observational study in Japanese journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Acquired bipolar cell disorder presenting with photophobia.BMC ophthalmology · 2025Article
- Acquired night blindness due to rod dysfunction after long-term hemodialysis.Japanese journal of ophthalmology · 2022Article
- Acute unilateral inner retinal dysfunction with photophobia: importance of electrodiagnosis.Japanese journal of ophthalmology · 2021Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeTo report the findings in 3 cases of bilateral negative electroretinograms (ERGs) with acute onset of photophobia. STUDY
designRetrospective case series.
methodsThe medical charts of the 3 patients were reviewed.
resultsA 43-year-old woman, a 68-year-old woman, and a 41-year-old woman were referred to Nagoya University Hospital. Their main symptom was bilateral acute photophobia. None of the patients had any systemic diseases or specific medical history. The decimal best-corrected visual acuity (> 0.8) and Humphrey visual fields (mean deviation > -3 dB) were relatively well preserved in all 3 patients. The optical coherence tomography (OCT) and fundus autofluorescence findings were essentially normal. Fluorescein angiography showed mild leakage in 1 patient but no abnormality in the other 2 patients. However, the ERGs of the 3 patients had the features of abnormal ERGs found in patients with incomplete congenital stationary night blindness (CSNB). Exome analyses found no pathogenic variants related to known CSNB-related genes. The symptoms and ERGs of the 3 patients have not progressed or recovered after a relatively long follow-up period.
conclusionThe ERG characteristics of 3 patients with bilateral photophobia were similar to those of incomplete CSNB, suggesting post-phototransductional abnormalities. The symptoms and genetic analyses indicated the possibility of an acquired condition rather than a hereditary retinal disease.
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