Evidence map›Paper›PMID 30604060›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

Effects of montelukast on human nasal mucosa.

Hsing-Won Wang, Jih-Chin Lee, Pei-Chuan Wu, Yueng-Hsiang Chu, Yuan-Yung Lin, Li-Hsiang Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Effects of liposomal nasal spray with vitamins A and E on allergic rhinitis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2020
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hsing-Won WangDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Cheng-Kung Road Section 2, Taipei, 114, Taiwan, ROC.
Jih-Chin LeeDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Cheng-Kung Road Section 2, Taipei, 114, Taiwan, ROC.
Pei-Chuan WuDepartment of Psychiatry, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC.
Yueng-Hsiang ChuDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Cheng-Kung Road Section 2, Taipei, 114, Taiwan, ROC.
Yuan-Yung LinDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Cheng-Kung Road Section 2, Taipei, 114, Taiwan, ROC.
Li-Hsiang ChengDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Cheng-Kung Road Section 2, Taipei, 114, Taiwan, ROC. doc30478@gmail.com.ORCID http://orcid.org/0000-0002-7566-0746
Tri-Service General Hospital · TWFar Eastern Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMontelukast is a selective and orally active leukotriene D

methodsThis study examined the effects of montelukast on human nasal mucosa in terms of mucosa resting tension, vasoconstriction caused by 10

resultsThe results indicated that addition of methoxamine to the incubation medium caused the nasal mucosa to vasocontract in a dose-dependent manner. Addition of montelukast at doses of 10

conclusionsThe study indicated significant vasodilation on human nasal mucosa under high concentrations of montelukast with a probable α-adrenoceptor antagonism. Hence, the nasal activity of α-adrenergic agonist nasal spray for nasal obstruction may be reduced in those using concomitant (oral or local spray) montelukast.

Indexed as

AcetatesAnti-Asthmatic AgentsCyclopropanesElectric StimulationHumansIn Vitro TechniquesLeukotriene AntagonistsMethoxamineMuscle, SmoothNasal MucosaNasal SpraysQuinolinesSulfidesVasoconstrictionVasoconstrictor AgentsAcetatesAnti-Asthmatic AgentsCyclopropanesLeukotriene AntagonistsMethoxaminemontelukastNasal SpraysQuinolinesSulfidesVasoconstrictor AgentsHuman nasal mucosaMontelukastSympathetic function

Identifiers

PMID30604060
OpenAlexW2908064374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.