ArticleBrain structure & function2019
Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain.
Article in Brain structure & function, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
- Multiple-context extinction strengthens fear suppression through hippocampal dopamine D2R-dependent memory updating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampus.eLife · 2026Article
- Downregulation of neuronal DRD2 drives microglia synaptic pruning and results in cognitive deficits by promoting CCL2 release in a rat model of chronic migraine.The journal of headache and pain · 2026Article
- Modulation of comorbid depression of neuropathic pain by dopamine input from VTA to the ventral hippocampus.Theranostics · 2025Article
- Rapid, biochemical tagging of cellular activity history in vivo.Nature methods · 2024Article
- Examining a punishment-related brain circuit with miniature fluorescence microscopes and deep learning.Addiction neuroscience · 2024Article
- Rapid, biochemical tagging of cellular activity history in vivo.bioRxiv : the preprint server for biology · 2024Article
- Amphetamine-induced dopamine release in rat: Whole-brain spatiotemporal analysis with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Intrinsic organization of the corpus callosum.Frontiers in physiology · 2024Review
- The Dynamics of Dopamine DNeuroscience bulletin · 2023Article
- Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain.Cell & bioscience · 2023Article
- Ghrelin system in Alzheimer's disease.Current opinion in neurobiology · 2023Review
- GRIN lens applications for studying neurobiology of substance use disorder.Addiction neuroscience · 2022Article
- Developing Photoaffinity Probes for Dopamine Receptor DACS chemical neuroscience · 2022Article
- Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats.Neurotoxicity research · 2022Article
- Olfactory regulation by dopamine and DRD2 receptor in the nose.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Striatal DFrontiers in aging neuroscience · 2022Article
- Dopamine D2 receptor regulates cortical synaptic pruning in rodents.Nature communications · 2021Article
- Reinforcement learning links spontaneous cortical dopamine impulses to reward.Current biology : CB · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The D2 dopamine receptor (Drd2) is implicated in several brain disorders such as schizophrenia, Parkinson's disease, and drug addiction. Drd2 is also the primary target of both antipsychotics and Parkinson's disease medications. Although the expression pattern of Drd2 is relatively well known in mouse brain, the temporal and spatial distribution of Drd2 is lesser clear in rat brain due to the lack of Drd2 reporter rat lines. Here, we used CRISPR/Cas9 techniques to generate two knockin rat lines: Drd2::Cre and Rosa26::loxp-stop-loxp-tdTomato. By crossing these two lines, we produced Drd2 reporter rats expressing the fluorescence protein tdTomato under the control of the endogenous Drd2 promoter. Using fluorescence imaging and unbiased stereology, we revealed the cellular expression pattern of Drd2 in adult and postnatal rat forebrain. Strikingly, the Drd2 expression pattern differs between Drd2 reporter rats and Drd2 reporter mice generated by BAC transgene in prefrontal cortex and hippocampus. These results provide fundamental information needed for the study of Drd2 function in rat forebrain. The Drd2::Cre rats generated here may represent a useful tool to study the function of neuronal populations expressing Drd2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.