Evidence map›Paper›PMID 30603982›Full record

ArticleNeurochemical research2019

Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils.

Howard C-H Shen, Yung-Han Chen, Yu-Sheng Lin, Brett K-Y Chu, Ching-Shin Liang, Chien-Chih Yang, Rita P-Y Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Cross-Seeding Assay in the Investigation of the Amyloid Core of Prion Fibrils.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Howard C-H ShenInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd, Nankang, Taipei, 11529, Taiwan.ORCID http://orcid.org/0000-0002-1663-0918
Yung-Han ChenInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd, Nankang, Taipei, 11529, Taiwan.
Yu-Sheng LinInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd, Nankang, Taipei, 11529, Taiwan.
Brett K-Y ChuInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd, Nankang, Taipei, 11529, Taiwan.
Ching-Shin LiangDepartment of Biochemical Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
Chien-Chih YangDepartment of Biochemical Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
Rita P-Y ChenInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd, Nankang, Taipei, 11529, Taiwan. pyc@gate.sinica.edu.tw.ORCID http://orcid.org/0000-0003-3987-033X
National Taiwan University · TWInstitute of Biological Chemistry, Academia Sinica · TW

Funding

The Ministry of Science and Technology (MOST) of Taiwan MOST 105-2119-M-001-028
6 · The paper itself

Abstract

Prion diseases are transmissible fatal neurodegenerative disorders affecting humans and other mammals. The disease transmission can occur between different species but is limited by the sequence homology between host and inoculum. The crucial molecular event in the progression of this disease is prion formation, starting from the conformational conversion of the normal, membrane-anchored prion protein (PrP

Indexed as

AmyloidAnimalsCricetinaeMicePeptide FragmentsPrion ProteinsProtein MultimerizationAmyloidPeptide FragmentsPrion ProteinsAmyloidCross-βFibrilHamsterPrionSeeding

Identifiers

PMID30603982
OpenAlexW2907474122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.