Evidence map›Paper›PMID 30603917›Full record

ArticleCytotechnology2019

Protective effects of cytokine combinations against the apoptotic activity of glucocorticoids on CD34

Serap Erdem Kuruca, Muzaffer Beyza Çetin, Kadriye Akgün Dar, Dilşad Özerkan

Open access · bronzeAbstract read
In one paragraph

Article in Cytotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Serap Erdem KurucaDeparment of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Muzaffer Beyza ÇetinDeparment of Physiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Kadriye Akgün DarDepartment of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.
Dilşad ÖzerkanDepartment of Genetic and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey. dilsadokan@gmail.com.ORCID http://orcid.org/0000-0002-0556-3879
Istanbul University · TRKastamonu University · TR

Funding

Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi 2980
6 · The paper itself

Abstract

Haematopoietic stem cells can self-renew and produce progenitor cells, which have a high proliferation capacity. Chemotherapeutic drugs are toxic to normal cells as well as cancer cells, and glucocorticoids (GCs), which are essential drugs for many chemotherapeutic protocols, efficiently induce apoptosis not only in malignant cells but also in normal haematopoietic cells. Studies have shown that haematopoietic cytokines can prevent the apoptosis induced by chemotherapy and decrease the toxic effects of these drugs. However, the apoptosis induction mechanism of GCs in CD34

Indexed as

ApoptosisCD34+ haematopoietic stem/progenitor cellsCytokinesGlucocorticoids

Identifiers

PMID30603917
PMCPMC6368496
OpenAlexW2906715596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.