ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2019
Gastric lymphatic flows may change before and after endoscopic submucosal dissection: in vivo porcine survival models.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 13 citations in OpenAlex.
- Variable sensitivity despite high detection rates: is sentinel node navigation surgery feasible following non-curative gastric ESD?International journal of surgery (London, England) · 2026Article
- Rethinking false-negative rate of sentinel node navigation surgery after non-curative endoscopic submucosal dissection: Insights from SENORITA 2 trial.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Letter to the Editor "Feasibility of sentinel basin mapping after non-curative endoscopic resection for early gastric cancer: a prospective multicenter cohort study (SENORITA 2 Trial)".International journal of surgery (London, England) · 2026Article
- Recent Advances in Sentinel Node Navigation Surgery for Early Gastric Cancer.Journal of gastric cancer · 2023Review
- Impact of non-curative endoscopic submucosal dissection on short- and long-term outcome of subsequent laparoscopic gastrectomy for pT1 gastric cancer.Surgical endoscopy · 2022Article
- Time to maximum indocyanine green fluorescence of gastric sentinel lymph nodes and feasibility of combined indocyanine green/sodium fluorescein gastric lymphography.Langenbeck's archives of surgery · 2021Article
- Current status and challenges in sentinel node navigation surgery for early gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021Article
- Recent updates and current issues of sentinel node navigation surgery for early gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021Article
- Essential updates 2019/2020: Perioperative and surgical management of gastric cancer.Annals of gastroenterological surgery · 2021Review
- Sentinel node mapping for post-endoscopic resection gastric cancer: multicenter retrospective cohort study in Japan.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Utility of the one-step nucleic acid amplification assay in sentinel node mapping for early gastric cancer patients.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Burgeoning study of sentinel-node analysis on management of early gastric cancer after endoscopic submucosal dissection.World journal of gastrointestinal endoscopy · 2020Review
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7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND STUDY
aimStandard gastrectomy with lymphadenectomy is recommended following endoscopic submucosal dissection (ESD) due to the risk of lymph-node metastasis for resected cancers. However, when lymphatic flows remain unchanged after ESD, a minimally invasive function-preserving surgery based on the sentinel node (SN) concept may be applicable. In this study, using porcine survival models, we aimed to investigate whether gastric lymphatic flows were modified following ESD.
methodsTwelve pigs, each with one simulating lesion 3 cm in size, were used. Indocyanine green (ICG) fluid was endoscopically injected into the submucosa in four quadrants surrounding the lesion. Following laparoscopic observation of lymphatic flows, the lesions were resected by ESD. After 4 weeks, ICG fluid was injected in four quadrants surrounding the scar and lymphatic flows were observed in the same manner as the initial procedure. The distribution of lymphatic flows, including stained SNs, was compared.
resultsIn ten lesions (83.3%), the distribution of flows remained unchanged. However, in one lesion, the flow along the right gastric epiploic artery (R-GEA) disappeared on the lesser curvature of the middle stomach. In addition, in one lesion, the flow along R-GEA emerged on the lesser curvature of the lower stomach.
conclusionsOur study revealed that, despite ESD, lymphatic flows remained unchanged in most parts of the stomach. The SN concept may be applied after ESD, except for lesions on the lesser curvature. However, in the case of the lesser curvature, special care must be given to the SN concept.
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