ArticleJournal of youth and adolescence2019
Youth Adversities Amplify the Association between Adult Stressors and Chronic Inflammation in a Domain Specific Manner: Nuancing the Early Life Sensitivity Model.
Article in Journal of youth and adolescence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing.Development and psychopathology · 2020Trial
- The divergent roles of childhood literacy and food availability in cognitive aging: evidence from two Chinese longitudinal datasets.The Gerontologist · 2026Observational
- Childhood exposure to danger increases Black youths' alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis.Development and psychopathology · 2025Article
- Stress Accumulation, Depressive Symptoms, and Sleep Problems among Black Americans in the Rural South.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- What is Common Becomes Normal; Black-White Variation in the Effects of Adversities on Subsequent Initiation of Tobacco and Marijuana During Transitioning into Adolescence.Journal of mental health & clinical psychology · 2024Article
- The Impact of Early and Recent Life Stress on Trajectories of Inflammatory Biomarkers in a Diverse Sample of Adolescents.Research on child and adolescent psychopathology · 2023Article
- Chronic Stress and Latent Virus Reactivation: Effects on Immune Aging, Chronic Disease Morbidity, and Mortality.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Racial discrimination, childhood adversity, and depression among Black men: Tests of stress sensitization hypotheses.Psychiatry research · 2023Article
- Examining the relationships between adverse childhood experiences (ACEs), cortisol, and inflammation among young adults.Brain, behavior, & immunity - health · 2022Article
- Adolescents' and young people's needs and preferences for support when living with a parent with life-threatening cancer: a grounded theory study.BMC palliative care · 2022Article
- Children and adolescents' preferences for support when living with a dying parent - An integrative review.Nursing open · 2022Review
- Life course trajectories of chronic financial strain and acute stress reactivity: Steeling in response to recovery from strain.Stress and health : journal of the International Society for the Investigation of Stress · 2022Article
- Non-invasive diagnosis and monitoring tool of children's mental health: A point-of-care immunosensor for IL-6 quantification in saliva samples.Frontiers in neuroscience · 2022Article
- Applications of psychoneuroimmunology models of toxic stress in prevention and intervention efforts across early development.Brain, behavior, & immunity - health · 2021Article
- The moderating effects of traumatic stress on vulnerability to emotional distress during pregnancy.Development and psychopathology · 2020Article
- Stress genomics revisited: gene co-expression analysis identifies molecular signatures associated with childhood adversity.Translational psychiatry · 2020Article
- Perceived Racial Discrimination and Marijuana Use a Decade Later; Gender Differences Among Black Youth.Frontiers in pediatrics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
There is strong evidence that chronic, systemic inflammation hastens onset of the diseases of old age that ultimately lead to death. Importantly, several studies suggest that childhood adversity predicts chronic inflammation. Unfortunately, this research has been plagued by retrospective reports of childhood adversity, an absence of controls for adult stressors, and a failure to investigate various competing models of the link between childhood adversity and chronic inflammation. The present study was designed to address these limitations. Using 18 years of data collected from 413 African Americans (58% female) included in the Family and Community Health Study, hierarchical regression analyses provided support for a nuanced early life sensitivity explanation for the link between early adversity and adult chronic inflammation. Controlling for health risk behaviors and adult SES, late childhood (ages 10-12) adversity amplified the association between adult adversity (age 29) and chronic inflammation. This interaction operated in a domain-specific fashion. Harsh parenting amplified the relation between intimate partner hostility and inflammation, whereas early discrimination amplified the relation between adult discrimination and inflammation. These findings suggest that individuals may be primed to respond physiologically to adverse adult circumstances that resemble those experienced earlier in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.