ReviewPediatric nephrology (Berlin, Germany)2020
Pheochromocytoma and paraganglioma-an update on diagnosis, evaluation, and management.
Review in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 128 citations in OpenAlex.
- Left ventricular thrombus formation in paraganglioma: a rare but serious complication - a case report.Annals of medicine and surgery (2012) · 2026Article
- Renal hilar paraganglioma with atypical clinical presentation and biochemical functionality: A case report of diagnostic pitfalls.Urology case reports · 2026Article
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
- Interdisciplinary vascular genetics evaluations in routine clinical care: insights from a five-year single-center experience.Langenbeck's archives of surgery · 2026Article
- Pheochromocytomas and Paragangliomas.Endocrinology and metabolism clinics of North America · 2026Review
- Acute renal hypoperfusion and reversible renal atrophy caused by renal hilar paraganglioma in a child: a case report.BMC nephrology · 2026Article
- Identification of prognostic signatures in pheochromocytomas and paragangliomas based on mitochondrial autophagy and ferroptosis in TCGA and GEO datasets.Discover oncology · 2026Article
- Incidental functional paraganglioma of the celiac space discovered during breast cancer staging: a case report.Journal of surgical case reports · 2025Article
- SDH defective cancers: molecular mechanisms and treatment strategies.Cell biology and toxicology · 2025Review
- Current Strategies for Managing Pheochromocytoma and Paraganglioma in Children and Adolescents.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers.Cancer medicine · 2025Review
- Evolution of metabolic disorders after resection of pheochromocytomas and paragangliomas: a single-center study.Medicine and pharmacy reports · 2025Article
- Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient.Frontiers in pediatrics · 2025Article
- Analysis of Urinary Metanephrines Using Liquid Chromatography Tandem Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Radioresistant mouse pheochromocytoma cell lines.Frontiers in oncology · 2025Article
- Multidisciplinary management of a rare case of a large functional paraganglioma in the posterior mediastinum in an adolescent: a case report and literature review.Frontiers in oncology · 2025Article
- Computed Tomography Radiomics Nomogram to Predict the Intraoperative Hypertensive Crisis of Abdominal Pheochromocytoma and Paraganglioma.Current medical imaging · 2025Article
- Perioperative Blood Pressure Management Recommendations in Pediatric Pheochromocytoma: A 10-Year Narrative Review.Kidney & blood pressure research · 2025Review
- Urinary bladder paraganglioma in pregnancy: a case report and literature review.Frontiers in medicine · 2025Article
- Unexpected pheochromocytoma leading to cardiac arrest during the perioperative period: a case report and literature review.BMC anesthesiology · 2024Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pheochromocytomas and paragangliomas (PPGLs) generally grouped together are rare catecholamine-secreting endocrine tumors. Symptoms of catecholamine excess are non-specific and therefore a high index of suspicion in children with sustained hypertension, family history of endocrine tumors, or features of syndromes associated with PPGLs leads to a timely diagnosis and treatment. Free metanephrines in the plasma or 24-h urine are the preferred tests to establish catecholamine excess. Considerations for false-positive conditions improve diagnostic yield and accuracy. Functional imaging, targeting either specific cell membrane transporters or vesicular catecholamine transport systems, is indicated for incidental lesions suspicious for PPGLs with inconclusive biochemical testing, assessment of regional extension or multifocality, and exclusion of metastases. Surgery is the mainstay of treatment for PPGLs. Preoperatively, sequential use of alpha adrenergic receptor blockade and volume expansion followed by beta blockade is mandatory to reduce intraoperative intravascular instability and blood pressure fluctuation due to tumor manipulation. Since genetic mutations have been reported in tumor susceptibility genes in nearly 50% of patients with PPGLs, genetic counselling and testing should be considered in all patients with a confirmed tumor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.