ArticleEuropean journal of applied physiology2019
Ramp and step increases in shear stress result in a similar magnitude of brachial artery flow-mediated dilation.
Article in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- The acute and chronic effects of local aerobic exercise on cardiovascular physiology.Experimental physiology · 2026Review
- Muscle temperature increases during a single far infrared sauna session without changes in intestinal temperature.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- The impact of repeated, local heating-induced increases in blood flow on lower limb endothelial function in young, healthy females.European journal of applied physiology · 2021Article
- Greater increase in internal carotid artery shear rate during aerobic interval compared to continuous exercise in healthy adult men.Physiological reports · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThere is evidence that the endothelium is responsive to both the rate and magnitude of increases in shear stress. However, whether flow-mediated dilation stimulated by sustained increases in shear stress (SS-FMD) is rate sensitive in humans is unknown. The purpose of this investigation was to test whether ramp (gradual) and step (instantaneous) increases in shear stress elicit disparate SS-FMD.
methodsYoung, healthy men (n = 18, age = 22 ± 2 years, body mass index = 25 ± 3 kg m
resultsShear rate was greater in the step versus ramp protocol in minutes 1-6, but not different thereafter. Similarly, SS-FMD was greater in the step versus ramp protocol during minutes 2-6, but similar in minutes 7-11 (minute 11: ramp 8.7 ± 4.6%; step 9.4 ± 3.6%; P = 0.343). SS-FMD continued to increase over time with maintenance of a steady shear stress stimulus (step minutes 2-11: 0.51 ± 0.36% min
conclusionsThese findings indicate that in the brachial artery of humans, the magnitude of SS-FMD is determined by the magnitude and duration, but not the rate, of increases in shear stress.
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