Evidence map›Paper›PMID 30603750›Full record

ReviewNanoscale2019

Applications of nanoparticles in biomedical imaging.

Xiangjun Han, Ke Xu, Olena Taratula, Khashayar Farsad

Abstract readReview
In one paragraph

Review in Nanoscale, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Green Synthesis of Silver Nanoparticles fromLife (Basel, Switzerland) · 2026
    Article
  6. Glucose coated FeO@FeScientific reports · 2026
    Article
  7. Article
  8. Article
  9. Applications of Nanobiotechnology in Medicine.Life (Basel, Switzerland) · 2026
    Review
  10. Article
  11. Article
  12. Optical and Photoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Tumor-Targeting TACS omega · 2025
    Article
  18. Article
  19. Review
  20. Review

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiangjun HanDepartment of Radiology, First Hospital of China Medical University, Shenyang, Liaoning, 110001 P. R. China. Kxu@cmu.edu.cn.
Ke Xu
Olena Taratula
Khashayar Farsad

Funding

Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
NCATS NIH HHS KL2 TR002370
6 · The paper itself

Abstract

An urgent need for early detection and diagnosis of diseases continuously pushes the advancements of imaging modalities and contrast agents. Current challenges remain for fast and detailed imaging of tissue microstructures and lesion characterization that could be achieved via development of nontoxic contrast agents with longer circulation time. Nanoparticle technology offers this possibility. Here, we review nanoparticle-based contrast agents employed in most common biomedical imaging modalities, including fluorescence imaging, MRI, CT, US, PET and SPECT, addressing their structure related features, advantages and limitations. Furthermore, their applications in each imaging modality are also reviewed using commonly studied examples. Future research will investigate multifunctional nanoplatforms to address safety, efficacy and theranostic capabilities. Nanoparticles as imaging contrast agents have promise to greatly benefit clinical practice.

Indexed as

Optical ImagingAnimalsContrast MediaHumansMagnetic Resonance ImagingNanoparticlesNeoplasmsPositron-Emission TomographyTomography, X-Ray ComputedUltrasonographyContrast Media

Identifiers

PMID30603750
PMCPMC8112886

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.