Evidence map›Paper›PMID 30603656›Full record

ArticleNeurophotonics2018

Cerebral metabolism in a mouse model of Alzheimer's disease characterized by two-photon fluorescence lifetime microscopy of intrinsic NADH.

Carlos A Gómez, Buyin Fu, Sava Sakadžić, Mohammad A Yaseen

Abstract read
In one paragraph

Article in Neurophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlos A GómezMassachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts, United States.
Buyin FuMassachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts, United States.
Sava SakadžićMassachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts, United States.
Mohammad A YaseenMassachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts, United States.

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
TRAINING PROGRAM IN QUANTITATIVE BIOLOGY AND PHYSIOLOGYT32GM008764 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WHITE, JOHN A. · 2001 to 2021
$5.9M
MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
Relating Neuroimmune and Neurovascular Alterations During Alzheimer's Disease ProgressionR01AA027097 · NIAAA · NORTHEASTERN UNIVERSITY · PI YASEEN, MOHAMMAD ABBAS · 2018 to 2022
$2.7M
Two-Photon Microscopy of Oxygen Consumption in the BrainR01NS091230 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA · 2015 to 2019
$2.4M
Multiscale Dynamic Measurements and Modeling of Cerebrovascular PhysiologyR01NS057476 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2007 to 2011
$2.0M
In Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime MicroscopyR00AG042026 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI YASEEN, MOHAMMAD ABBAS · 2015 to 2017
$747k
NIAAA NIH HHS R01 AA027097NIA NIH HHS R00 AG042026NIGMS NIH HHS T32 GM008764NIMH NIH HHS R01 MH111359NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS057476NINDS NIH HHS R01 NS091230
6 · The paper itself

Abstract

Disruptions and alterations to cerebral energy metabolism play a vital role in the onset and progression of many neurodegenerative disorders and cerebral pathologies. In order to precisely understand the complex alterations underlying Alzheimer's disease (AD) progression,

Indexed as

Alzheimer’s diseasecerebral metabolismfluorescence lifetime imagingmicroscopyphasors

Identifiers

PMID30603656
PMCPMC6307680

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.