ReviewTissue engineering and regenerative medicine2018
In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine.
Review in Tissue engineering and regenerative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The current status of nano-hydrogel preparations for osteochondral repair: Systematic Review.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Clinical translation of injectable hydrogels: from bioactive polymers to long-acting drug delivery systems.Drug delivery and translational research · 2026Review
- Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential.Gels (Basel, Switzerland) · 2025Review
- A Bibliometric Analysis and Systematic Review of Research Advances in In Situ Gel Drug Delivery Systems from 2003 to 2023.Pharmaceutics · 2025Review
- Zinc Peroxide-Mediated In Situ Forming Hydrogels for Endogenous Tissue Regeneration.Biomaterials research · 2025Article
- Free and encapsulated stem cells for skin regeneration.BioImpacts : BI · 2025Review
- Rheology as a Tool for Fine-Tuning the Properties of Printable Bioinspired Gels.Molecules (Basel, Switzerland) · 2023Review
- Controlled Release in Hydrogels Using DNA Nanotechnology.Biomedicines · 2022Article
- In Situ Hydrogels for Effective Treatment of Cancer: Strategies and Polymers Used.Recent advances in drug delivery and formulation · 2022Article
- Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment.Pharmaceutics · 2021Review
- Assessing the mechanisms of action of natural molecules/extracts for phase-directed wound healing in hydrogel scaffolds.RSC medicinal chemistry · 2021Review
- Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021Review
- Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy.Cancers · 2020Article
- Printability and Shape Fidelity of Bioinks in 3D Bioprinting.Chemical reviews · 2020Review
- Comparison of Scaffolds Fabricated via 3D Printing and Salt Leaching: In Vivo Imaging, Biodegradation, and Inflammation.Polymers · 2020Article
- Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia.Frontiers in bioengineering and biotechnology · 2020Review
- Review
- Dual-Channel Fluorescence Imaging of Hydrogel Degradation and Tissue Regeneration in the Brain.Theranostics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymeric hydrogels are extensively used as promising biomaterials in a broad range of biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. These materials have advantages such as structural similarity to the native extracellular matrix (ECM), multi-tunable physicochemical and biological properties, and biocompatibility.
methodsIn situ forming hydrogels show a phase transition from a solution to a gel state through various physical and chemical cross-linking reactions. These advanced hydrogel materials have been widely used for tissue regenerative medicine because of the ease of encapsulating therapeutic agents, such as cells, drugs, proteins, and genes.
resultsWith advances in biomaterials engineering, these hydrogel materials have been utilized as either artificial cellular microenvironments to create engineered tissue constructs or as bioactive acellular matrices to stimulate the native ECM for enhanced tissue regeneration and restoration.
conclusionIn this review, we discuss the use of in situ cross-linkable hydrogels in tissue engineering and regenerative medicine applications. In particular, we focus on emerging technologies as a powerful therapeutic tool for tissue regenerative medicine applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.