Evidence map›Paper›PMID 30603577›Full record

ReviewTissue engineering and regenerative medicine2018

Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications.

Janarthanan Gopinathan, Insup Noh

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tissue engineering and regenerative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 152 citations in OpenAlex.

  1. Review
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  3. Thiolated Polymers in 3D Bioprinting: Control of Gelation.Advanced materials (Deerfield Beach, Fla.) · 2026
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  15. Injectable Dendritic Hydrogels Curable by High-Energy Visible Light for Cell Delivery in Bone Regeneration.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Janarthanan Gopinathan1Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology (Seoul Tech), 232 Gongneung-ro, Nowon-Gu, Seoul, 01811 Republic of Korea.
Insup Noh1Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology (Seoul Tech), 232 Gongneung-ro, Nowon-Gu, Seoul, 01811 Republic of Korea.ORCID 0000-0003-0696-7768
Seoul National University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe tissue engineering and regenerative medicine approach require biomaterials which are biocompatible, easily reproducible in less time, biodegradable and should be able to generate complex three-dimensional (3D) structures to mimic the native tissue structures. Click chemistry offers the much-needed multifunctional hydrogel materials which are interesting biomaterials for the tissue engineering and bioprinting inks applications owing to their excellent ability to form hydrogels with printability instantly and to retain the live cells in their 3D network without losing the mechanical integrity even under swollen state.

methodsIn this review, we present the recent developments of

resultsThe click chemistry-based hydrogels are formed spontaneously on mixing of reactive compounds and can encapsulate live cells with high viability for a long time. The recent works reported by combining the advantages of click chemistry and 3D bioprinting technology have shown to produce 3D tissue constructs with high resolution using biocompatible hydrogels as bioinks and

conclusionInterestingly, the emergence of click chemistry reactions in bioink synthesis for 3D bioprinting have shown the massive potential of these reaction methods in creating 3D tissue constructs. However, the limitations and challenges involved in the click chemistry reactions should be analyzed and bettered to be applied to tissue engineering and 3D bioinks. The future scope of these materials is promising, including their applications in

Indexed as

3D bioprintingClick chemistryHydrogelsRegenerative medicineTissue engineering

Identifiers

PMID30603577
PMCPMC6171698
OpenAlexW2886661380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.