ArticleTissue engineering and regenerative medicine2018
A Non-woven Path: Electrospun Poly(lactic acid) Scaffolds for Kidney Tissue Engineering.
Article in Tissue engineering and regenerative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Versatile twin layer macromolecular fibers for advanced tissue engineering applications.iScience · 2026Article
- A dynamic bioreactor for endothelial and epithelial cell co-culture to mimic aspects of renal microenvironments.Biomedical microdevices · 2026Article
- Thermoforming for Small Feature Replication in Melt Electrowritten Membranes to Model Kidney Proximal Tubule.Advanced healthcare materials · 2025Article
- Effective and new technologies in kidney tissue engineering.Frontiers in bioengineering and biotechnology · 2024Review
- Evaluation of Random and Aligned Polycaprolactone Nanofibrous Electrospun Scaffold for Human Periodontal Ligament Engineering in Biohybrid Titanium Implants.International journal of dentistry · 2024Article
- Cryo-Electrospinning Generates Highly Porous Fiber Scaffolds Which Improves Trabecular Meshwork Cell Infiltration.Journal of functional biomaterials · 2023Article
- A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering.Bioengineering (Basel, Switzerland) · 2022Review
- Engineering cryoelectrospun elastin-alginate scaffolds to serve as stromal extracellular matrices.Biofabrication · 2022Article
- Electrospinning Fabrication Methods to Incorporate Laminin in Polycaprolactone for Kidney Tissue Engineering.Tissue engineering and regenerative medicine · 2022Article
- Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies.ACS biomaterials science & engineering · 2021Review
- Electrospun fibre diameter and its effects on vascular smooth muscle cells.Journal of materials science. Materials in medicine · 2021Article
- Influence of surface topography on PCL electrospun scaffolds for liver tissue engineering.Journal of materials chemistry. B · 2021Article
- In Vitro Strategies to Vascularize 3D Physiologically Relevant Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- 3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration.Small science · 2021Article
- Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin-induced diabetic nephropathy rats.IET nanobiotechnology · 2021Article
- Response differences of HepG2 and Primary Mouse Hepatocytes to morphological changes in electrospun PCL scaffolds.Scientific reports · 2021Article
- High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine.Tissue engineering. Part C, Methods · 2020Article
- Integrational Technologies for the Development of Three-Dimensional Scaffolds as Platforms in Cartilage Tissue Engineering.ACS omega · 2020Article
- Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Hybrid Additive Microfabrication Scaffold Incorporated with Highly Aligned Nanofibers for Musculoskeletal Tissues.Tissue engineering and regenerative medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Chronic kidney disease is a major global health problem affecting millions of people; kidney tissue engineering provides an opportunity to better understand this disease, and has the capacity to provide a cure. Two-dimensional cell culture and decellularised tissue have been the main focus of this research thus far, but despite promising results these methods are not without their shortcomings. Polymer fabrication techniques such as electrospinning have the potential to provide a non-woven path for kidney tissue engineering. In this experiment we isolated rat primary kidney cells which were seeded on electrospun poly(lactic acid) scaffolds. Our results showed that the scaffolds were capable of sustaining a multi-population of kidney cells, determined by the presence of: aquaporin-1 (proximal tubules), aquaporin-2 (collecting ducts), synaptopodin (glomerular epithelia) and von Willebrand factor (glomerular endothelia cells), viability of cells appeared to be unaffected by fibre diameter. The ability of electrospun polymer scaffold to act as a conveyor for kidney cells makes them an ideal candidate within kidney tissue engineering; the non-woven path provides benefits over decellularised tissue by offering a high morphological control as well as providing superior mechanical properties with degradation over a tuneable time frame.
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