ArticleTissue engineering and regenerative medicine2016
Bone morphogenetic protein-2 sustained delivery by hydrogels with microspheres repairs rabbit mandibular defects.
Article in Tissue engineering and regenerative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Advanced Hydrogel systems for mandibular reconstruction.Bioactive materials · 2023Review
- The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin.Maxillofacial plastic and reconstructive surgery · 2023Article
- Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects.Frontiers in aging · 2023Review
- Rational design of hydrogels to enhance osteogenic potential.Chemistry of materials : a publication of the American Chemical Society · 2020Article
- Recent advances in periodontal regeneration: A biomaterial perspective.Bioactive materials · 2020Article
- Implantable electrical stimulation bioreactor with liquid crystal polymer-based electrodes for enhanced bone regeneration at mandibular large defects in rabbit.Medical & biological engineering & computing · 2020Article
- Response Surface Methodology for Statistical Optimization of Chitosan/Alginate Nanoparticles as a Vehicle for Recombinant Human Bone Morphogenetic Protein-2 Delivery.International journal of nanomedicine · 2020Article
- Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status.Tissue engineering and regenerative medicine · 2018Review
- Electrostatically Interactive Injectable Hydrogels for Drug Delivery.Tissue engineering and regenerative medicine · 2018Review
- Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications.Tissue engineering and regenerative medicine · 2018Review
- Thermoresponsive and Biodegradable Amphiphilic Block Copolymers with Pendant Functional Groups.Tissue engineering and regenerative medicine · 2018Article
- Synthesis and Biocompatibility Characterizations of in Situ Chondroitin Sulfate-Gelatin Hydrogel for Tissue Engineering.Tissue engineering and regenerative medicine · 2018Article
- Oral Immunization of FMDV Vaccine Using pH-Sensitive and Mucoadhesive Thiolated Cellulose Acetate Phthalate Microparticles.Tissue engineering and regenerative medicine · 2018Article
- Effect of Drug Carrier Melting Points on Drug Release of Dexamethasone-Loaded Microspheres.Tissue engineering and regenerative medicine · 2017Article
- BMP2-modified injectable hydrogel for osteogenic differentiation of human periodontal ligament stem cells.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mandible defect is a difficult issue in dental surgery owing to limited therapeutic options. Recombinant human bone morphogenetic protein-2 (rhBMP2) is osteoinductive in bone regeneration. This article prepared chitosan/collagen hydrogels with rhBMP2-incorporated gelatin microsphere (GMs) for a sustained release of rhBMP2 to induce bone regeneration in rabbits. In experiments, mandibular defects of 8 mm in diameter and 3 mm in depth were surgically prepared on the right cheek of 27 rabbits. Either chitosan/collagen hydrogels alone, rhBMP2-incorporated hydrogels, or hydrogels with rhBMP2-incorporated GMs were implanted to the defect sites. The animals were euthanized at 2, 6, 12 weeks following surgery. In results, scanning electronic microscope images revealled spherical GMs. The complex delivery systems, hydrogels with rhBMP2-incorporated GMs, exhibited ideal release profiles
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.