ReviewTissue engineering and regenerative medicine2016
Signaling of extracellular matrices for tissue regeneration and therapeutics.
Review in Tissue engineering and regenerative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Fibroblast-Derived ECM as a Donor-Specific Pro-Osteogenic Coating Surpassing ASC- and Osteoblast-Derived ECM.Journal of functional biomaterials · 2026Article
- The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration.Stem cell research & therapy · 2025Review
- Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate.Tissue engineering and regenerative medicine · 2024Article
- Real and Simulated Microgravity: Focus on Mammalian Extracellular Matrix.Life (Basel, Switzerland) · 2022Review
- Article
- Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review.Frontiers in bioengineering and biotechnology · 2022Review
- New physiological insights into the phenomena of deer antler: A unique model for skeletal tissue regeneration.Journal of orthopaedic translation · 2021Review
- 3D bioprinting in cardiac tissue engineering.Theranostics · 2021Review
- Genipin Cross-Linked Decellularized Nucleus Pulposus Hydrogel-Like Cell Delivery System Induces Differentiation of ADSCs and Retards Intervertebral Disc Degeneration.Frontiers in bioengineering and biotechnology · 2021Article
- Osteoblast/fibroblast coculture derived bioactive ECM with unique matrisome profile facilitates bone regeneration.Bioactive materials · 2020Article
- Review of Plastic Surgery Biomaterials and Current Progress in Their 3D Manufacturing Technology.Materials (Basel, Switzerland) · 2020Review
- A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.Stem cell research & therapy · 2020Article
- Bacteriophage-based biomaterials for tissue regeneration.Advanced drug delivery reviews · 2019Review
- Mechanically Reinforced Extracellular Matrix Scaffold for Application of Cartilage Tissue Engineering.Tissue engineering and regenerative medicine · 2018Article
- Endogenous Stem Cells in Homeostasis and Aging.Tissue engineering and regenerative medicine · 2017Article
- Intracellular Remodeling and Accumulation of Aberrant Lysosomes in Differentiation of Tonsil-Derived Mesenchymal Stem Cells into Parathyroid-Like Cells.Tissue engineering and regenerative medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells receive important regulatory signals from their extracellular matrix (ECM) and the physical property of the ECM regulates important cellular behaviors like cell proliferation, migration and differentiation. A large part of tissue formation and regeneration depends on cellular interaction with its ECM. A comprehensive understanding of the mechanistic biochemical pathway of the ECM components is necessary for the design of a biomaterial scaffold for tissue engineering. Depending on the type of tissue, the ECM requirement might be different and this would influence its downstream intracellular cell signaling. Here, we reviewed the ECM and its signaling pathway by discussing: 1) classification of the ECM into hard, elastic and soft tissue based on its physical properties, 2) proliferation and differentiation control of the ECM, 3) roles of membrane receptor and its intracellular regulation factor, 4) ECM remodeling via inside-out signaling. By providing a comprehensive overview of the ECM's role in mechanotransduction and the self-regulatory effect of cells back on the ECM, we hope to provide a better insight of the physical and biochemical cues from the ECM. A sound understanding on the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.