Evidence map›Paper›PMID 30603376›Full record

ArticlePneumonia (Nathan Qld.)2018

Impact of the 23-valent pneumococcal polysaccharide vaccination in pregnancy against infant acute lower respiratory infections in the Northern Territory of Australia.

Michael J Binks, Sarah A Moberley, Anne Balloch, Amanda J Leach, Sandra Nelson, Kim M Hare, Cate Wilson, Jane Nelson, Peter S Morris, Robert S Ware and 5 more

Registry-linked trialAbstract read
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In one paragraph

Article in Pneumonia (Nathan Qld.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00714064 (PneuMum), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00714064 phase3completednot on this map

PneuMum: A Randomised Controlled Trial of Pneumococcal Polysaccharide Vaccination for Aboriginal and Torres Strait Islander Mothers to Protect Their Babies From Ear Disease

TypeinterventionalSponsorMenzies School of Health ResearchRan2006 to 2011Enrolled227ConditionsMiddle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal InfectionsArms23vPPV, dTpa (Pneumovax, Boostrix)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael J Binks1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.ORCID 0000-0001-5455-690X
Sarah A Moberley1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.
Anne Balloch2Murdoch Children's Research Institute, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria Australia.
Amanda J Leach1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.
Sandra NelsonDepartment of Health and Families, Darwin, Northern Territory Australia.
Kim M Hare1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.
Cate Wilson1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.
Jane Nelson1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.
Peter S Morris1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.
Robert S WareMenzies Health Institute Queensland, Griffith University, Gold Coast; Child Health Research Centre, School of Medicine, The University of Queensland, Queensland, Brisbane, Australia.
Mimi L K Tang2Murdoch Children's Research Institute, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria Australia.
Paul J Torzillo5Royal Prince Alfred Hospital, Sydney, New South Wales Australia.
Jonathan R CarapetisTelethon Kids Institute, University of Western Australia, Perth Children's Hospital, Perth, Western Australia Australia.
Kim Mulholland2Murdoch Children's Research Institute, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria Australia.
Ross M Andrews1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0810 Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndigenous children in Australia's Northern Territory are densely colonised with the pneumococcus within weeks of birth antecedent to a high prevalence of acute lower respiratory infection (ALRI). We assessed the impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in pregnancy against infant ALRI in this setting.

methodsIn an open label, allocation concealed, outcome-assessor blinded, randomised controlled trial conducted in the Northern Territory of Australia, healthy Indigenous women aged 17-39 years were randomised to receive the 23vPPV during pregnancy (

resultsALRI hospitalisation incidence was 12.3 per 100 child-years among infants of pregnancy vaccinees compared with 15.8 per 100 child-years among controls (hazard ratio (HR) 0.77, 95%CI 0.29-2.03). ALRI hospitalisations were more common among remote compared to urban infants (27.7 versus 8.6 per 100 child-years). Stratification by dwelling highlighted a differential antenatal vaccine effect against ALRI hospitalisations (

conclusionsIn this small study, antenatal 23vPPV vaccination was not associated with a reduced incidence of infant ALRI hospitalisations or ALRI clinic presentations during the first year of life. A potential differential effect between urban and remote settings warrants further investigation.

trial registrationPneuMum; ClinicalTrials.gov NCT00714064.

Indexed as

23-valent pneumococcal polysaccharide vaccineAcute lower respiratory infectionAustraliaIndigenousPregnancy

Identifiers

PMID30603376
PMCPMC6305569

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Registered trials

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