ArticleDiabetology international2016
Efficacy and safety assessment of basal supported oral therapy (BOT) with insulin glargine in a real-life clinical setting, stratified by concomitant orally administered antidiabetic agent (OAD) regimens including dipeptidyl peptidase-4 inhibitor (DPP-4i): subanalysis of the ALOHA2 study, drug-use surveillance in Japan.
Article in Diabetology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Glycemic Patterns Assessed by Continuous Glucose Monitoring in People with Type 2 Diabetes Treated with Insulin Glargine 100 U/mL in Primary Care: The GPDetect Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Article
- Comparison of medication persistence and adherence in type 2 diabetes using a once-weekly regimen of DPP-4 inhibitor compared with once-daily and twice-daily regimens: a retrospective cohort study of Japanese health insurance claims data.Diabetology international · 2024Article
- Clinical Evidence and Practice-Based Guidelines on the Utility of Basal Insulin Combined Oral Therapy (Metformin and Glimepiride) in the Current Era.Current diabetes reviews · 2023Review
- Use of Insulin Glargine 100 U/mL for the Treatment of Type 2 Diabetes Mellitus in East Asians: A Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Review
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS AND
introductionWe aimed to explore concomitant orally administered antidiabetic agent (OAD) regimens used in basal supported oral therapy (BOT) with insulin glargine in a real-life setting, and to assess the efficacy and safety of each regimen using data from the Add-on Lantus MATERIALS AND
methodsAmong 1629 insulin-naïve patients who had a glycosylated hemoglobin (HbA1c) value of ≥6.5 % during the previous 4 weeks and were treated with BOT during the observational period, 1227 patients who retained the same concomitant OAD regimens throughout the period were included in the analysis.
resultsSulfonylurea (71.5 %), dipeptidyl peptidase-4 inhibitor (DPP-4i; 60.7 %), and biguanide (BG; 48.6 %) were commonly administered OADs in BOT. The HbA1c level decreased in patients taking BG alone (-2.76 %) and DPP-4i alone (-2.46 %). Of the three OADs, mean doses of the most frequently administered OAD changed from baseline to the final evaluation point: 2.5-2.3 mg for glimepiride, 59.1-58.7 mg for sitagliptin, and 1145.6-1168.2 mg for metformin. No significant difference in the hypoglycemia incidence rate was found between regimens (
conclusionsDPP-4i plays a major role in BOT with insulin glargine in a real-life setting. The incidence of hypoglycemia did not differ significantly between BOT regimens, including DPP-4i. Insulin glargine added to DPP-4i is a potential therapeutic approach.
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