Evidence map›Paper›PMID 30603154›Full record

ArticleBiomedical engineering letters2017

Limitations and artifacts in shear-wave elastography of the liver.

Matthew Bruce, Orpheus Kolokythas, Giovanna Ferraioli, Carlo Filice, Matthew O'Donnell

Abstract read
In one paragraph

Article in Biomedical engineering letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew Bruce1Applied Physics Lab, University of Washington, Seattle, WA 98195 USA.ORCID 0000-0002-9302-5922
Orpheus Kolokythas2Department of Radiology, University of Washington, Seattle, WA 98195 USA.
Giovanna Ferraioli3Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.
Carlo Filice3Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.
Matthew O'Donnell4Department of Bioengineering, University of Washington, Seattle, WA 98195 USA.

Funding

q4DE: A Biomarker for Image-Guided, Post-MI Hydrogel TherapyR01HL121226 · NHLBI · YALE UNIVERSITY · PI DUNCAN, JAMES S, O'DONNELL, MATTHEW · 2014 to 2022
$6.3M
Optical coherence elastography of corneal dynamicsR01EY026532 · NEI · UNIVERSITY OF WASHINGTON · PI SHEN, TUENG T · 2016 to 2020
$2.9M
Nano-agent for photoacoustic theranostics of dialysis graft/fistula occlusionsR01HL125339 · NHLBI · UNIVERSITY OF WASHINGTON · PI POZZO, LILO D. · 2015 to 2019
$2.8M
Sensitive tumor detection with magnetomotive imagingR01CA170734 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2012 to 2015
$1.8M
Non-invasive trapping and imaging of circulating tumor cells in the peripheral vaR01EB016034 · NIBIB · UNIVERSITY OF WASHINGTON · PI O'DONNELL, MATTHEW · 2013 to 2016
$1.7M
NCI NIH HHS R01 CA170734NEI NIH HHS R01 EY026532NHLBI NIH HHS R01 HL121226NHLBI NIH HHS R01 HL125339NIBIB NIH HHS R01 EB016034
6 · The paper itself

Abstract

Recent studies have shown that real-time, two-dimensional shear-wave elastography (2D-SWE) can monitor liver fibrosis by measuring tissue elasticity (i.e., elastic modulus). Two clinical studies of 2D-SWE in the liver have shown that there are several practical issues that can compromise quantitation of liver tissue elasticity. Both general ultrasound (US) limitations and limitations in the 2D-SWE method itself resulted in significant variability in estimated liver elasticity. The most common US limitations were: poor acoustic window, limited penetration, and rib/lung shadows. The most common 2D-SWE limitations were: reverberations under the liver capsule, respiratory/cardiac motion, and vessel pulsation/loss of SWE signal. Based on these studies, scan protocols have been optimized to minimize the influence of these limitations on liver elasticity quantification. These refined protocols should move non-invasive SWE closer to becoming the preferred tool to diagnose and manage many chronic diseases of the liver.

Indexed as

Acoustic radiation forceFibrosisLiver stiffnessShear modulusShear-wave elasticity imagingShear-wave speed

Identifiers

PMID30603154
PMCPMC6208474

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.