ArticleJournal of gastrointestinal oncology2018
Exploring the differences between early-onset gastric cancer and traditional-onset gastric cancer.
Article in Journal of gastrointestinal oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Young-Onset Gastric Cancer: Clinical and Genetic Perspectives.Journal of gastric cancer · 2026Review
- Application of deep learning models in gastric cancer pathology image analysis: a systematic scoping review.BMC cancer · 2025Article
- A Longitudinal Study of Premalignant Gastric Lesions and Early Onset Gastric Cancer Among Young Adults in Central Saudi Arabia.Current oncology (Toronto, Ont.) · 2025Observational
- Bone Metastasis Mediates Poor Prognosis in Early-Onset Gastric Cancer: Insights Into Immune Suppression, Coagulopathy, and Inflammation.Cancer medicine · 2025Article
- Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young- and Average-Onset Gastric Cancer.Cancer medicine · 2024Article
- Gastric Cancer: An Up-to-Date Review with New Insights into Early-Onset Gastric Cancer.Cancers · 2024Review
- Review
- Early-onset gastrointestinal cancer: An epidemiological reality with great significance and implications.World journal of gastrointestinal oncology · 2024Article
- Is early-onset cancer an emerging global epidemic? Current evidence and future implications.Nature reviews. Clinical oncology · 2022Review
- Practical Considerations in Diagnosing and Managing Early-Onset GI Cancers.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- Article
- Comparison of treatment strategies and survival of early-onset gastric cancer: a population-based study.Scientific reports · 2022Article
- Multi‑institutional development and validation of a nomogram to predict prognosis of early-onset gastric cancer patients.Frontiers in immunology · 2022Article
- Clinical, Molecular and Genetic Characteristics of Early Onset Gastric Cancer: Analysis of a Large Multicenter Study.Cancers · 2021Article
- Comparative investigation of early-onset gastric cancer.Oncology letters · 2021Review
- Higher Lymph Node Metastasis Rate and Poorer Prognosis of Intestinal-Type Gastric Cancer Compared to Diffuse-Type Gastric Cancer in Early-Onset Early-Stage Gastric Cancer: A Retrospective Study.Frontiers in medicine · 2021Article
- Comparison of metastasis between early-onset and late-onset gastric signet ring cell carcinoma.BMC gastroenterology · 2020Article
- Article
- Germline variants and phenotypic spectrum in a Canadian cohort of individuals with diffuse gastric cancer.Current oncology (Toronto, Ont.) · 2020Article
- Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer.American journal of cancer research · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current study sought to explore the potential clinical, epidemiological and genetic differences between early-onset gastric cancer (E-gastric cancer: defined as 20-39 years) and traditional-onset gastric cancer (T-gastric cancer: defined as ≥40 years).
methodsDatasets from the following sources were searched: Surveillance, Epidemiology and End Results database [2000-2014], Behavioral Risk Factor Surveillance Survey and the cancer genome atlas (TCGA). Clinicopathological characteristics, trends, and genetic findings were compared between E-gastric cancer and T-gastric cancer. Moreover, correlations with relevant risk factors were sought after.
resultsA total of 95,323 gastric cancer patients were identified in the period from 2000 to 2014. While T-gastric cancer was decreasing during the study period (-1.4; P<0.05), E-gastric cancer was stable during the study period. E-gastric cancer is less prevalent in males (51.1%
conclusionsE-gastric cancer is a potentially distinct disease entity with specific clinicopathological and trend patterns compared to conventional T-gastric cancer. Further studies are needed to explore the potential etiologic basis as well as to investigate the clinical consequences of this distinction. The impact of this distinction on minority populations requires further assessment as well.
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