ArticleAfrican health sciences2018
Thyroid function in healthy and unhealthy preterm newborns.
Article in African health sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Relationship between thyroid hormones and bronchopulmonary dysplasia in extremely and very preterm infants.Frontiers in physiology · 2026Article
- Lack of difference in thyroid hormone profile between offspring conceived naturally and through ART.Human reproduction open · 2026Article
- Article
- An analysis of perinatal factors of low T3 syndrome in preterm neonates with a gestational age of 28-35 weeks.Annals of medicine · 2021Article
- Transient hypothyroxinemia of prematurity and its risk factors in an extramural neonatal intensive care unit.Archives of endocrinology and metabolism · 2021Article
- Sexuality and other issues in Africa and beyond.African health sciences · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe thyroid gland and hormonal regulation are among the most important systems to be investigated in pre-term infants. This study sought to investigate thyroid hormone levels of healthy and unhealthy pre-term infants.
methodsThe prospective study included 53 consecutive premature infants admitted to the neonatal intensive care unit within a duration of one year. Of these preterm babies, 20 were healthy, while 33 had problems such as asphyxia or RDS. Venous blood samples were collected at baseline 0-24 hours, 7 and 14 days and FT3, FT4, and TSH levels were determined. Other data recorded included demographic characteristics of the patients and clinical variables.
resultsThe most frequent health problems were RDS (87.9%), sepsis (30.3%), and retinopathy of prematurity (24.2%). The mean TSH levels showed a consistent decline at three consequent measurements in both groups, which were always significantly lower in unhealthy pre-terms. In both groups, TSH levels showed significant decreases on Day 7 and Day 14 compared to the baseline levels (p<005). The levels of FT3 and FT4 consistently showed significant correlations with gestational week and birth weight at each of the three measurements.
conclusionPre-term infants, especially those having problems, have significant hypothyroxinemia that may require thyroid hormone replacement therapy.
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