ArticleNature2019
A wireless closed-loop system for optogenetic peripheral neuromodulation.
Abstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers.
0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
191 citing papers in PubMed.
- Local control of Cre-regulated genetic modeling in vivo using wireless implantable optoelectronics.Science advances · 2026Article
- Battery-free, fully wireless neurostimulation via radiative RF power transfer in freely behaving mice.Microsystems & nanoengineering · 2026Article
- The potential of soft robotics for the restoration of urinary voiding.Nature reviews. Urology · 2026Review
- Multiscale biomimetic design for peripheral nerve repair: Beyond passive bridging.Materials today. Bio · 2026Review
- Untethered thin-film neurostimulator wrapped around tiny nerve trunks for wireless neuromodulation.Science advances · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Should We Consider Sacral Nerve Stimulation as a Treatment for Neurogenic Lower Urinary Tract Dysfunction? ICI-RS 2025.Neurourology and urodynamics · 2026Review
- Approaching-unity PLQY and high stretchability in polymer emitters via molecular spacers.Nature communications · 2026Article
- Low-power analog and mixed-signal circuit techniques for next-generation miniature implantable neural interface systems.Biomedical engineering letters · 2026Review
- Wireless electrostimulation implants enable sphincter neuromuscular improvement toward mixed urinary incontinence.Nature communications · 2026Article
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- "Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.Nature communications · 2026Article
- Implantable soft bladder-machine interface for neurogenic bladder dysfunction.Nature communications · 2026Article
- Closed-loop neuromodulation: a paradigm shift in precision neuroscience for clinical and cognitive applications.Frontiers in neuroscience · 2026Review
- From microfluidics to nanodelivery: artificial intelligence reshapes neuropharmacology research strategies.Frontiers in pharmacology · 2026Review
- Recent Technological Advances in Monitoring and Neuromodulation of Non-Malignant and Neurogenic Bladder Conditions.Advanced healthcare materials · 2026Review
- UROREC: A cystometry and electromyography recording system for analyzing urinary incontinence parameters in rat models.PloS one · 2026Article
- From concept to practice: intra-articular photobiomodulation for knee osteoarthritis.Frontiers in immunology · 2026Review
- Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025Review
131 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
25 authors.
Aaron D Mickle *Washington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Sang Min Won *Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kyung Nim Noh *Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jangyeol Yoon *Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kathleen W MeachamWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Yeguang XueDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
Lisa A McIlvriedWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Bryan A CopitsWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Vijay K SamineniWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Kaitlyn E CrawfordDepartment of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA.
Do Hoon KimDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Paulome SrivastavaWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Bong Hoon KimDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Seunghwan MinDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Young ShiuanWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Yeojeong YunDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Maria A PayneWashington University School of Medicine, St Louis, MO, USA.
Jianpeng ZhangInstitute of Solid Mechanics, Beihang University (BUAA), Beijing, China.
Hokyung JangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Yuhang LiInstitute of Solid Mechanics, Beihang University (BUAA), Beijing, China.
H Henry LaiWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.
Yonggang HuangDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
Sung-Il ParkDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.
Robert W GereauWashington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA. gereaur@wustl.edu.
John A RogersDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. jrogers@northwestern.edu.
Funding
Washington University MAPP Network Discovery SiteU01DK082315 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2008 to 2021
$9.0MBIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8MMECHANISMS OF PERIPHERAL MGLUR MODULATION OF NOCICEPTIONR01NS042595 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2002 to 2017
$5.2MTRAINING PROGRAM IN ANESTHESIOLOGY RESEARCHT32GM108539 · NIGMS · WASHINGTON UNIVERSITY · PI Aaron J Norris · 2014 to 2026
$4.9MMultimodal biocompatible microLED devices for diverse neuroscience applicationsR01NS081707 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W, ROGERS, JOHN · 2012 to 2016
$3.9MImaging, Modeling and Engineering of Diabetic TissuesT32DK108742 · NIDDK · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2016 to 2020
$1.4MSoft, conformal wireless optoelectronic systems for the long-term neuromodulation of bladder functionU18EB021793 · NIBIB · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W, ROGERS, JOHN · 2015 to 2018
$877kTHE ROLE OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) IN BLADDER PAINK08DK094964 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2017
$700kDEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERSK01DK115634 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2018 to 2022
$582kClosed Loop Wireless Monitoring and Optogenetic Modulation of Bladder FunctionF32DK115122 · NIDDK · WASHINGTON UNIVERSITY · PI MICKLE, AARON DAVID · 2017 to 2018
$118kNIBIB NIH HHS U18 EB021793NIDA NIH HHS T32 DA007261NIDDK NIH HHS F32 DK115122NIDDK NIH HHS K01 DK115634NIDDK NIH HHS K08 DK094964NIDDK NIH HHS T32 DK108742NIDDK NIH HHS U01 DK082315NIGMS NIH HHS T32 GM108539NINDS NIH HHS R01 NS042595NINDS NIH HHS R01 NS081707
Abstract
The fast-growing field of bioelectronic medicine aims to develop engineered systems that can relieve clinical conditions by stimulating the peripheral nervous system
Indexed as
AlgorithmsAnimalsCells, CulturedElectronicsFemaleGanglia, SpinalHumansNeuronsOptogeneticsRatsRats, Sprague-DawleySpinal Nerve RootsUrinary BladderWireless Technology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.