Evidence map›Paper›PMID 30602790›Full record

ArticleNature2019

GABA

Simonas Masiulis, Rooma Desai, Tomasz Uchański, Itziar Serna Martin, Duncan Laverty, Dimple Karia, Tomas Malinauskas, Jasenko Zivanov, Els Pardon, Abhay Kotecha and 3 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 293 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
293citing papers in PubMed, 2 pooled it
25.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

293 citing papers in PubMed, 2 syntheses or guidelines pooled it, 340 citations in OpenAlex.

  1. Cys-loop receptors on cannabinoids: All high?Frontiers in physiology · 2022
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
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  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Metabotropic signaling downstream of GABANPJ Parkinson's disease · 2026
    Article
  17. GABACellular and molecular neurobiology · 2026
    Review
  18. Article
  19. Article
  20. Human GlyRα2 pore dynamics in gating and inhibition.Structure (London, England : 1993) · 2026
    Article

233 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Simonas MasiulisMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK. simonasm@mrc-lmb.cam.ac.uk.
Rooma DesaiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tomasz UchańskiStructural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Itziar Serna MartinDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Duncan LavertyMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Dimple KariaDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Tomas MalinauskasDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Jasenko ZivanovMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Els PardonStructural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Abhay KotechaMaterials and Structural Analysis, Thermo Fisher Scientific, Eindhoven, The Netherlands.
Jan SteyaertStructural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Keith W MillerDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. kwmiller@mgh.harvard.edu.
A Radu AricescuMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK. radu@mrc-lmb.cam.ac.uk.
MRC Laboratory of Molecular Biology · GBVIB-VUB Center for Structural Biology · BECentre for Human Genetics · GBMassachusetts General Hospital · USUniversity of Oxford · GBThermo Fisher Scientific (Netherlands) · NL

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 1999 to 2018
$33.6M
Medical Research Council MC_EX_MR/L009609/2Medical Research Council MC_UP_1201/15Medical Research Council MC_UP_A025_1013Medical Research Council MR/L009609/1NIGMS NIH HHS P01 GM058448
6 · The paper itself

Abstract

Type-A γ-aminobutyric (GABA

Indexed as

Cryoelectron MicroscopyAllosteric RegulationAlprazolamBenzodiazepinesBicucullineBinding, CompetitiveDiazepamGABA ModulatorsHumansLigandsModels, MolecularNanostructuresPicrotoxinReceptors, GABA-ASignal TransductionAlprazolamBenzodiazepinesBicucullineDiazepamGABA ModulatorsLigandsPicrotoxinReceptors, GABA-A

Identifiers

PMID30602790
PMCPMC6370056
OpenAlexW2907708451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.