Evidence map›Paper›PMID 30602786›Full record

ArticleNature2019

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery.

Minako Ito, Kyoko Komai, Setsuko Mise-Omata, Mana Iizuka-Koga, Yoshiko Noguchi, Taisuke Kondo, Ryota Sakai, Kazuhiko Matsuo, Takashi Nakayama, Osamu Yoshie and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 482 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
482citing papers in PubMed, 4 pooled it
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

482 citing papers in PubMed, 4 syntheses or guidelines pooled it, 776 citations in OpenAlex.

  1. Pooled it
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  18. TTNCell reports · 2026
    Article
  19. Review
  20. Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026
    Article

422 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Minako ItoDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan. ito@a3.keio.jp.
Kyoko KomaiDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Setsuko Mise-OmataDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Mana Iizuka-KogaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Yoshiko NoguchiDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Taisuke KondoDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Ryota SakaiDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Kazuhiko MatsuoDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-Osaka, Japan.
Takashi NakayamaDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-Osaka, Japan.
Osamu YoshieThe Health and Kampo Institute, Sendai, Japan.
Hiroko NakatsukasaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Shunsuke ChikumaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Takashi ShichitaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Akihiko YoshimuraDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan. yoshimura@a6.keio.jp.
Keio University · JPKindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to maintaining immune tolerance, FOXP3

Indexed as

AnimalsAstrocytesBrainBrain IschemiaCell MovementCell ProliferationChemokine CCL1Chemokine CCL20GliosisInterleukin-2Interleukin-33Interleukin-6MaleMiceMice, Inbred C57BLNeuroprotectionCcl1 protein, mouseCCL20 protein, mouseChemokine CCL1Chemokine CCL20Interleukin-2Interleukin-33Interleukin-6Receptors, Antigen, T-CellReceptors, CCRReceptors, SerotoninSerotoninserotonin 7 receptorStat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID30602786
OpenAlexW2906480617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.