ArticleNature communications2019
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.
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116citing papers in PubMed, 1 pooled it
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Who cites it
116 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imbalance of Peripheral Lymphocyte Subsets in Patients With Ankylosing Spondylitis: A Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Effects of Secukinumab on Enthesiophyte and Erosion Progression in Psoriatic Arthritis: A One-Year Double-Blind, Randomized, Placebo-Controlled Trial Using High-Resolution Peripheral Quantitative Computed Tomography.Arthritis & rheumatology (Hoboken, N.J.) · 2025Trial
- Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534.Scientific reports · 2021Trial
- Molecular Signature and miRNA Pattern of CD4 + T Lymphocytes in Plaque Psoriasis.Clinical reviews in allergy & immunology · 2026Review
- A temporal differentiation program after birth delineates γδ T cell immunity.Science advances · 2026Article
- Killer-cell immunoglobulin-like receptors define a potent effector program in human γδ T cells.JCI insight · 2026Article
- From IL-23/IL-17 to GM-CSF: how is the immuno-inflammatory continuum reshaped in spondyloarthritis?Frontiers in immunology · 2026Review
- Comment on: Psoriasis under B-cell depleting therapies in multiple sclerosis: a retrospective multicenter analysis.Therapeutic advances in neurological disorders · 2026Article
- Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025Review
- Phenotypic Remodeling of γδ T Cells in Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyposis.Medicina (Kaunas, Lithuania) · 2025Article
- Phantom of the immunologic opera: Unmasking the role of innate lymphoid cells (ILC) in inborn errors of immunity (IEI).Journal of human immunity · 2025Review
- Advances in Psoriasis Research: Decoding Immune Circuits and Developing Novel Therapies.International journal of molecular sciences · 2025Review
- What can Animal Models tell us About T Cells in Spondyloarthritis Pathogenesis?Current rheumatology reports · 2025Review
- Treatment with cyclosporine attenuates the inflammatory process and severity of bisphosphonate-induced osteonecrosis of the jaws in rats.Inflammopharmacology · 2025Article
- Article
- Transcription factors in the development and treatment of immune disorders.Transcription · 2025Review
- Interleukin-17 Inhibitors in the Treatment of Hidradenitis Suppurativa.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025Review
- Biomarkers for successful tapering of a tumor necrosis factor inhibitor in patients with radiographic axial spondyloarthritis: A pilot study.SAGE open medicine · 2025Article
- The IL-23R and Its Genetic Variants: A Hitherto Unforeseen Bridge Between the Immune System and Cancer Development.Cancers · 2024Review
- No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies.Heliyon · 2024Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors.
Koen VenkenDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium. koen.venken@ugent.be.
Peggy JacquesDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Céline MortierDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Mark E LabadiaResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Tine DecruyDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Julie CoudenysDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Kathleen HoytResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Anita L WayneResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Robert HughesResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Michael TurnerResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Sofie Van GassenVIB Inflammation Research Center, Ghent University, Technologiepark 71, 9052, Ghent, Belgium.
Liesbet MartensVIB Inflammation Research Center, Ghent University, Technologiepark 71, 9052, Ghent, Belgium.ORCID http://orcid.org/0000-0001-9180-7456
Dustin SmithResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Christian HarckenResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Joseph WahleResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Chao-Ting WangResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Eveline VerheugenDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Nadia SchryversDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Gaëlle VarkasDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Heleen CypersDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Ruth WittoekDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Yves PietteDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Lieve GyselbrechtASZ Aalst, Merestraat 80, 9300, Aalst, Belgium.
Serge Van CalenberghLaboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9052, Gent, Belgium.ORCID http://orcid.org/0000-0002-4201-1264
Filip Van den BoschDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.
Yvan SaeysVIB Inflammation Research Center, Ghent University, Technologiepark 71, 9052, Ghent, Belgium.
Gerald NaboznyResearch and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA.
Dirk ElewautDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium. dirk.elewaut@ugent.be.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and γδ-T cells, but their contribution to SpA is still unclear. Here we describe the presence of particular RORγt
Indexed as
Case-Control StudiesHumansInterleukin-17Natural Killer T-CellsNuclear Receptor Subfamily 1, Group F, Member 3Receptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinSpondylarthritisT-Lymphocyte SubsetsIL23R protein, humanInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Receptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinRORC protein, human
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