ArticleNature communications2019
Selective single molecule sequencing and assembly of a human Y chromosome of African origin.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Insights into natural neocentromere evolution from a cattle T2T X chromosome.Nature communications · 2025Article
- Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms.Nucleic acids research · 2025Article
- An effective strategy for assembling the sex-limited chromosome.GigaScience · 2024Article
- Article
- Y chromosome sequence and epigenomic reconstruction across human populations.Communications biology · 2023Article
- Origin and chromatin remodeling of young X/Y sex chromosomes in catfish with sexual plasticity.National science review · 2023Article
- Benchmarking of human Y-chromosomal haplogroup classifiers with whole-genome and whole-exome sequence data.Computational and structural biotechnology journal · 2023Article
- Noninvasive prenatal prediction of fetal haplotype with Spearman rank correlation analysis model.Molecular genetics & genomic medicine · 2022Article
- Genomic architecture of 5S rDNA cluster and its variations within and between species.BMC genomics · 2022Article
- Sex-specific splicing of Z- and W-borneProceedings of the National Academy of Sciences of the United States of America · 2022Article
- A convergent mechanism of sex determination in dioecious plants: Distinct sex-determining genes display converged regulation on floral B-class genes.Frontiers in plant science · 2022Review
- Chromosome-scale reference genome assembly of a diploid potato clone derived from an elite variety.G3 (Bethesda, Md.) · 2021Article
- Applications and potentials of nanopore sequencing in the (epi)genome and (epi)transcriptome era.Innovation (Cambridge (Mass.)) · 2021Review
- A near complete genome for goat genetic and genomic research.Genetics, selection, evolution : GSE · 2021Article
- A Hu sheep genome with the first ovine Y chromosome reveal introgression history after sheep domestication.Science China. Life sciences · 2021Article
- The Genomic Architecture and Evolutionary Fates of Supergenes.Genome biology and evolution · 2021Review
- Genomic Tackling of Human Satellite DNA: Breaking Barriers through Time.International journal of molecular sciences · 2021Review
- Noninvasive prenatal testing for β-thalassemia by targeted nanopore sequencing combined with relative haplotype dosage (RHDO): a feasibility study.Scientific reports · 2021Article
- Efficient assembly of nanopore reads via highly accurate and intact error correction.Nature communications · 2021Article
- Using Combined Methods of Genetic Mapping and Nanopore-Based Sequencing Technology to Analyze the Insertion Positions ofFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic regions, only a handful of species have their Y chromosome properly characterized. To date, just a single human reference quality Y chromosome, of European ancestry, is available due to a lack of accessible methodology. To facilitate the assembly of such complicated genomic territory, we developed a novel strategy to sequence native, unamplified flow sorted DNA on a MinION nanopore sequencing device. Our approach yields a highly continuous assembly of the first human Y chromosome of African origin. It constitutes a significant improvement over comparable previous methods, increasing continuity by more than 800%. Sequencing native DNA also allows to take advantage of the nanopore signal data to detect epigenetic modifications in situ. This approach is in theory generalizable to any species simplifying the assembly of extremely large and repetitive genomes.
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Registered trials
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