Evidence map›Paper›PMID 30602772›Full record

ReviewNature cell biology2019

Super-resolution microscopy demystified.

Lothar Schermelleh, Alexia Ferrand, Thomas Huser, Christian Eggeling, Markus Sauer, Oliver Biehlmaier, Gregor P C Drummen

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06105177 (Implementation of Up-front ctDNA Analysis Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - the Lungmarker² Study), which is not on this map. Cited by 526 papers.

0numbers the graph read from it
0cells of the map it votes in
526citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06105177 recruitingnot on this mapstarted 2023, after this paper: background citation

Implementation of Up-front ctDNA Analysis Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - the Lungmarker² Study

Typeobservational_patient_registrySponsorCatharina Ziekenhuis EindhovenRan2023 to 2026Enrolled800ConditionsLung Cancer
3 · Its place in the literature

Who cites it

526 citing papers in PubMed.

  1. Non-Covalent Reversibly Photoconvertible Fluorescent Tags for Wash-Free Protein Labeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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466 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lothar SchermellehMicron Oxford Advanced Bioimaging Unit, Department of Biochemistry, University of Oxford, Oxford, UK. lothar.schermelleh@bioch.ox.ac.uk.ORCID http://orcid.org/0000-0002-1612-9699
Alexia FerrandImaging Core Facility, Biozentrum, University of Basel, Basel, Switzerland.
Thomas HuserBiomolecular Photonics, Department of Physics, University of Bielefeld, Bielefeld, Germany.ORCID http://orcid.org/0000-0003-2348-7416
Christian EggelingMRC Human Immunology Unit and Wolfson Imaging Centre Oxford, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Markus SauerDepartment of Biotechnology & Biophysics, Biocenter, Julius Maximilian University of Würzburg, Würzburg, Germany.
Oliver BiehlmaierImaging Core Facility, Biozentrum, University of Basel, Basel, Switzerland.
Gregor P C DrummenAdvanced Bio-Imaging Program, Bio&Nano Solutions‒LAB3BIO, Bielefeld, Germany. gpcdrummen@bionano-solutions.de.ORCID http://orcid.org/0000-0002-8746-7062

Funding

Medical Research Council G0902418Medical Research Council MC_UU_00008/9Medical Research Council MC_UU_12010/9Medical Research Council MR/K01577X/1
6 · The paper itself

Abstract

Super-resolution microscopy (SRM) bypasses the diffraction limit, a physical barrier that restricts the optical resolution to roughly 250 nm and was previously thought to be impenetrable. SRM techniques allow the visualization of subcellular organization with unprecedented detail, but also confront biologists with the challenge of selecting the best-suited approach for their particular research question. Here, we provide guidance on how to use SRM techniques advantageously for investigating cellular structures and dynamics to promote new discoveries.

Indexed as

AnimalsCell BiologyHumansImaging, Three-DimensionalMicroscopy, FluorescenceMolecular BiologyReproducibility of Results

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.