Evidence map›Paper›PMID 30602770›Full record

ReviewNature cell biology2019

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication.

Mathilde Mathieu, Lorena Martin-Jaular, Grégory Lavieu, Clotilde Théry

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06469892 (Application of Salivary and Plasma Exosomes in the Diagnosis of Oral Leukoplakia Malignant Transformation and Prognosis Monitoring of Oral Cancer), which is not on this map. Cited by 2,249 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,249citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06469892 completednot on this mapstarted 2020, after this paper: background citation

Application of Salivary and Plasma Exosomes in the Diagnosis of Oral Leukoplakia Malignant Transformation and Prognosis Monitoring of Oral Cancer

Typeobservational_patient_registrySponsorBeijing Stomatological Hospital, Capital Medical UniversityRan2020 to 2023Enrolled225ConditionsOral Leukoplakia, Oral CancerArmsDetect the expression level of miR-185 in salivary and plasma exosomes.
3 · Its place in the literature

Who cites it

2,249 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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2,189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mathilde MathieuInstitut Curie, PSL Research University, INSERM U932, Paris, France.
Lorena Martin-JaularInstitut Curie, PSL Research University, INSERM U932, Paris, France.ORCID http://orcid.org/0000-0002-1511-8576
Grégory LavieuInstitut Curie, PSL Research University, INSERM U932, Paris, France.
Clotilde ThéryInstitut Curie, PSL Research University, INSERM U932, Paris, France. clotilde.thery@curie.fr.ORCID http://orcid.org/0000-0001-8294-6884

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ill-defined. Here, we discuss the current knowledge on the specificities of exosomes and other types of extracellular vesicles, and their roles as important agents of cell-to-cell communication.

Indexed as

Actin CytoskeletonBiological TransportCell CommunicationCell MembraneExosomesExtracellular VesiclesHumansModels, Biological

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.