Evidence map›Paper›PMID 30602723›Full record

ReviewNature cell biology2019

Integrin trafficking in cells and tissues.

Paulina Moreno-Layseca, Jaroslav Icha, Hellyeh Hamidi, Johanna Ivaska

Abstract readReview
In one paragraph

Review in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Mechanical forces stimulate Golgi export.The Journal of cell biology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Moesin is an αCellular and molecular life sciences : CMLS · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Integrins as key regulators in tumor perineural invasion: mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  15. Article
  16. Article
  17. The emerging role of integrin signaling in pulmonary vascular disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  18. Detection of Mesenchymal Stem Cell Aging Using an Integrin Mechano-Probe.Annals of the New York Academy of Sciences · 2026
    Article
  19. Review
  20. Review

219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paulina Moreno-Layseca *Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Jaroslav Icha *Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Hellyeh Hamidi *Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Johanna IvaskaTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland. johanna.ivaska@utu.fi.ORCID http://orcid.org/0000-0002-6295-6556

Funding

European Research Council 615258
6 · The paper itself

Abstract

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.

Indexed as

EndocytosisSignal TransductionAnimalsCell AdhesionCell MembraneCell MovementHumansIntegrinsModels, BiologicalProtein TransportIntegrins

Identifiers

PMID30602723
PMCPMC6597357

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.