Evidence map›Paper›PMID 30602686›Full record

ArticleMolecules (Basel, Switzerland)2018

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation.

Joana Moreira, Diana Ribeiro, Patrícia M A Silva, Nair Nazareth, Madalena Monteiro, Andreia Palmeira, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa, Honorina Cidade

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Joana MoreiraLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. joana.m26@hotmail.com.
Diana RibeiroCESPU, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal. diana.ribeiro@cespu.pt.
Patrícia M A SilvaCESPU, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal. patricia.silva@cespu.pt.ORCID 0000-0002-0694-7321
Nair NazarethLAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. naircampos@gmail.com.
Madalena MonteiroLAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madsmonteiro@gmail.com.ORCID 0000-0001-8672-9756
Andreia PalmeiraLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. andreiapalmeira@gmail.com.
Lucília SaraivaLAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. lucilia.saraiva@ff.up.pt.ORCID 0000-0002-9531-4939
Madalena PintoLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt.ORCID 0000-0002-4676-1409
Hassan BousbaaInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. hassan.bousbaa@iucs.cespu.pt.ORCID 0000-0002-4006-5779
Honorina CidadeLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. hcidade@ff.up.pt.ORCID 0000-0003-0715-1779
Universidade do Porto · PTCooperativa de Ensino Superior Politécnico e Universitário · PT

Funding

Fundação para a Ciência e a Tecnologia UID/Multi/04423/2013, UID/MULTI/04378/2013, PTDC/SAU-PUB/28736/2014 (reference POCI-01-0145-FEDER-028736), PTDC/MAR-BIO/4694/2014 (reference POCI-01-0145-FEDER-016790; Project 3599-PPCDT), PTDC/AAG-TEC/0739/2014 (reference POCI-01-0145-FEDER-016793; Proje
6 · The paper itself

Abstract

The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the discovery of new compounds with improved antitumor activity through the activation of caspase-7 activity. The synthesis of twenty-five flavonoids (

Indexed as

Antineoplastic AgentsCaspase 7Caspase InhibitorsCell CycleCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorFlavonesGene Expression Regulation, NeoplasticHumansMCF-7 CellsMolecular Docking SimulationMolecular StructureQuantitative Structure-Activity RelationshipAntineoplastic AgentsCASP7 protein, humanCaspase 7Caspase InhibitorsFlavonesalkylationantitumor activityapoptosiscaspase activatorsflavonoidsO-heterocycles

Identifiers

PMID30602686
PMCPMC6337158
OpenAlexW2907615645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.