ArticleBlood2019
Disrupted filamin A/α
Open access · bronzeAbstract read
In one paragraph
Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Expanded clinical, genetic, and biological spectrum of filaminopathies with hematological involvement.Haematologica · 2026Article
- ITGA2B/ITGB3-Related Macrothrombocytopenia Associated With Gain-of-Function Mutations in ITGA2B or ITGB3 Genes.Journal of cellular and molecular medicine · 2026Review
- Filamin a binds deleted in liver cancer 1 (DLC1) to promote its tumor suppressor activity and inhibit the SRF coactivator MRTF-A.Neoplasia (New York, N.Y.) · 2026Article
- α-Actinin-1 in Megakaryocytes: Its Structure, Interacting Proteins and Implications for Thrombopoiesis.Biomedicines · 2025Review
- Increased RhoA pathway activation downstream of αIIbβ3/SRC contributes to heterozygous Bernard Soulier syndrome.Haematologica · 2025Article
- A nonactivatingBlood vessels, thrombosis & hemostasis · 2025Article
- Differentially expressed platelet activation-related genes in dogs with stage B2 myxomatous mitral valve disease.BMC veterinary research · 2023Article
- Article
- Mutation of FLNA attenuating the migration of abdominal muscles contributed to Melnick-Needles syndrome (MNS) in a family with recurrent miscarriage.Molecular genetics & genomic medicine · 2023Article
- Structure, signal transduction, activation, and inhibition of integrin αIIbβ3.Thrombosis journal · 2023Review
- The actin cytoskeleton: Morphological changes in pre- and fully developed lung cancer.Biophysics reviews · 2022Review
- A gain-of-function filamin A mutation in mouse platelets induces thrombus instability.Journal of thrombosis and haemostasis : JTH · 2022Article
- Integrins and their role in megakaryocyte development and function.Experimental hematology · 2022Review
- New insights into regulation of αIIbβ3 integrin signaling by filamin A.Research and practice in thrombosis and haemostasis · 2022Article
- Migfilin: Cell Adhesion Effect and Comorbidities.OncoTargets and therapy · 2022Review
- A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome.Nature communications · 2021Article
- Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells.Scientific reports · 2021Article
- iPSC diversity: A key for better use and improved targeting.Journal of thrombosis and haemostasis : JTH · 2021Article
- Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients.eLife · 2021Article
- Direct Comparison of Four Hematopoietic Differentiation Methods from Human Induced Pluripotent Stem Cells.Stem cell reports · 2020Article
Corrections and comments
- Commented on byα2019
Authors and funding
17 authors at 2 institutions in 1 country.
Alessandro DonadaUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-3091-3313
Nathalie BalaynUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Dominika SliwaUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Larissa LordierUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Valentina CegliaUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Francesco BaschieriUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-0218-5320
Cyril GoizetCentre de Référence Neurogénétique, Hôpital Pellegrin, University Hospital of Bordeaux, Bordeaux, France.
Rémi FavierUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-1850-6686
Lucie ToscaUMR 967, INSERM, Service d'Histologie Embryologie et Cytogénétique, Hôpitaux Universitaires Paris-Sud, AP-HP, Clamart, France; and.ORCID 0000-0003-2766-8265
Gérard TachdjianUMR 967, INSERM, Service d'Histologie Embryologie et Cytogénétique, Hôpitaux Universitaires Paris-Sud, AP-HP, Clamart, France; and.ORCID 0000-0001-7043-6609
Cecile V DenisHémostase, Inflammation, Thrombose, UMR S1176, INSERM, Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.ORCID 0000-0001-5152-9156
Isabelle PloUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.ORCID 0000-0002-5915-6910
William VainchenkerUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-4705-202X
Najet DebiliUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Jean-Philippe RosaHémostase, Inflammation, Thrombose, UMR S1176, INSERM, Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.ORCID 0000-0001-7342-0389
Marijke BryckaertHémostase, Inflammation, Thrombose, UMR S1176, INSERM, Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.ORCID 0000-0003-3398-0976
Hana RaslovaUnité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.ORCID 0000-0001-8846-5299
Université Paris-Sud · FRInserm · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamin A (FLNa) links the cell membrane with the cytoskeleton and is central in several cellular processes. Heterozygous mutations in the X-linked
Indexed as
FemaleFibrinogenFilaminsHumansMegakaryocytesMutationPlatelet Glycoprotein GPIIb-IIIa ComplexProtein BindingrhoA GTP-Binding Proteinrho-Associated KinasesThrombocytopeniaFibrinogenFilaminsFLNA protein, humanPlatelet Glycoprotein GPIIb-IIIa ComplexrhoA GTP-Binding Proteinrho-Associated KinasesROCK1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.