ArticleThe Journal of pharmacology and experimental therapeutics2019
The HNF1
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Beyond the Very Important Pharmacogenes (VIPs): Uncovering Shadow Pharmacogenes in the Human Drug Response Network.ACS omega · 2026Article
- Unraveling the Regulatory Impact of LncRNA Hnf1aos1 on Hepatic Homeostasis in Mice.Non-coding RNA · 2025Article
- Mechanism of Panax notoginseng saponins modulation of miR-214-3p/NR1I3 affecting the pharmacodynamics and pharmacokinetics of warfarin.Journal of ginseng research · 2024Article
- Article
- Genome-Wide Exploration of Long Non-Coding RNAs ofInsects · 2024Article
- Epigenetic Mechanisms Contribute to Intraindividual Variations of Drug Metabolism Mediated by Cytochrome P450 Enzymes.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells.Drug metabolism and disposition: the biological fate of chemicals · 2022Article
- Alterations of Cytochrome P450-Mediated Drug Metabolism during Liver Repair and Regeneration after Acetaminophen-Induced Liver Injury in Mice.Drug metabolism and disposition: the biological fate of chemicals · 2022Article
- From pharmacogenetics to pharmaco-omics: Milestones and future directions.HGG advances · 2022Review
- Non-coding RNA crosstalk with nuclear receptors in liver disease.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.Archives of toxicology · 2021Review
- Molecular effects and retinopathy induced by hydroxychloroquine during SARS-CoV-2 therapy: Role of CYP450 isoforms and epigenetic modulations.European journal of pharmacology · 2020Review
- Review
- Role of non-coding-RNAs in response to environmental stressors and consequences on human health.Redox biology · 2020Review
- The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases.Non-coding RNA · 2020Review
- Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1Molecular pharmacology · 2020Article
- Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells.Drug metabolism and disposition: the biological fate of chemicals · 2020Article
- Long-noncoding RNAs (lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance.Acta pharmaceutica Sinica. B · 2020Review
- Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics.Biochemical pharmacology · 2019Review
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Yiting WangDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Liang YanDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Jingyang LiuDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Shitong ChenDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Guangming LiuDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Yali NieDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Pei WangDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Weihong YangDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Liming ChenDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Xiaobo ZhongDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.).
Shengna HanDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.) zhanglirongzzu@126.com hanshengna@126.com.
Lirong ZhangDepartment of Pharmacology (Y.W., L.Y., J.L., S.C., G.L., Y.N., P.W., S.H., L.Z.) and Forensic Medicine (W.Y.), School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (L.Y.); and Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (L.C., X.Z.) zhanglirongzzu@126.com hanshengna@126.com.
First Affiliated Hospital of Zhengzhou University · CNZhengzhou University · CNUniversity of Connecticut · US
Funding
Short- or long-term impacts of drug exposure at early life on drug metabolism, therapeutic efficacy, and drug-induced toxicityR01GM118367 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI ZHONG, XIAO-BO · 2016 to 2019
$1.2MNIGMS NIH HHS R01 GM118367
Abstract
Expression of cytochrome P450s (P450s) is regulated by epigenetic factors, such as DNA methylation, histone modifications, and noncoding RNAs through different mechanisms. Among these factors, long noncoding RNAs (lncRNAs) have been shown to play important roles in the regulation of gene expression; however, little is known about the effects of lncRNAs on the regulation of P450 expression. The aim of this study was to explore the role of lncRNAs in the regulation of P450 expression by using human liver tissues and hepatoma Huh7 cells. Through lncRNA microarray analysis and quantitative polymerase chain reaction in human liver tissues, we found that the lncRNA hepatocyte nuclear factor 1 alpha antisense 1 (HNF1
Indexed as
Cell Line, TumorCytochrome P-450 Enzyme SystemGene ExpressionHepatocyte Nuclear Factor 1-alphaHumansLiverRNA, Long NoncodingCytochrome P-450 Enzyme SystemHepatocyte Nuclear Factor 1-alphaHNF1A protein, humanlong non-coding RNA HNF1A-AS1, humanRNA, Long Noncoding
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.