Evidence map›Paper›PMID 30602568›Full record

ArticleThe Journal of biological chemistry2019

Phosphatidylserine synthesis is essential for viability of the human fungal pathogen

Paulina Konarzewska, Yina Wang, Gil-Soo Han, Kwok Jian Goh, Yong-Gui Gao, George M Carman, Chaoyang Xue

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Phosphatidylcholine biosynthesis pathways inFrontiers in cellular and infection microbiology · 2025
    Article
  4. Magnolol Inhibits the Growth ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Loss of Opi3 causes a lipid imbalance that influences the virulence traits ofFrontiers in cellular and infection microbiology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Mapping the Substrate-Binding Sites in the Phosphatidylserine Synthase inFrontiers in cellular and infection microbiology · 2021
    Article
  17. Role of lipid transporters in fungal physiology and pathogenicity.Computational and structural biotechnology journal · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 5 countries.

Paulina KonarzewskaFrom the Public Health Research Institute and.
Yina WangFrom the Public Health Research Institute and.
Gil-Soo Hanthe Rutgers Center for Lipid Research and.
Kwok Jian Gohthe School of Biological Sciences, Nanyang Technological University, Singapore 117597, Singapore.
Yong-Gui Gaothe School of Biological Sciences, Nanyang Technological University, Singapore 117597, Singapore.
George M Carmanthe Rutgers Center for Lipid Research and.ORCID 0000-0003-4951-8233
Chaoyang XueFrom the Public Health Research Institute and xuech@njms.rutgers.edu.ORCID 0000-0001-8196-1468
Rutgers, The State University of New Jersey · USNanyang Technological University · SG

Funding

The role of inositol in Cryptococcus biology and pathogenesisR01AI123315 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Chaoyang Xue · 2017 to 2026
$5.0M
Phospholipid metabolism and membrane functionR37GM028140 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI CARMAN, GEORGE M. · 2010 to 2019
$4.0M
NIAID NIH HHS R01 AI123315NIGMS NIH HHS R37 GM028140
6 · The paper itself

Abstract

Phospholipids are an integral part of the cellular membrane structure and can be produced by a

Indexed as

Microbial ViabilityAnimalsCDPdiacylglycerol-Serine O-PhosphatidyltransferaseCryptococcus neoformansCytidine Diphosphate DiglyceridesEndoplasmic ReticulumFungal ProteinsHumansPhosphatidylserinesSaccharomyces cerevisiaeCDPdiacylglycerol-Serine O-PhosphatidyltransferaseCytidine Diphosphate DiglyceridesFungal ProteinsPhosphatidylserinesantifungal drugCryptococcus neoformansfungiinositol phospholipidmicrobial pathogenesismitochondriaphosphatidylserinephosphatidylserine synthasephospholipid metabolismreactive oxygen speciesvirulence

Identifiers

PMID30602568
PMCPMC6378964
OpenAlexW2907099309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.