Evidence map›Paper›PMID 30602504›Full record

ArticleInfection and immunity2019

Biochemical and Immunological Evaluation of Recombinant CS6-Derived Subunit Enterotoxigenic Escherichia coli Vaccine Candidates.

Steven T Poole, Milton Maciel, Premkumar Dinadayala, Kathleen E Dori, Annette L McVeigh, Yang Liu, Eileen Barry, Christen Grassel, Michael G Prouty, Geneviève Renauld-Mongénie and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Optimization of EnterotoxigenicMicroorganisms · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Evaluation of a Live AttenuatedPathogens (Basel, Switzerland) · 2021
    Article
  14. Review
  15. Confronting challenges to enterotoxigenicFrontiers in tropical diseases · 2021
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Steven T Poole *Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA steven.t.poole.ctr@mail.mil milton.maciel.ctr@mail.mil.
Milton Maciel *Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA steven.t.poole.ctr@mail.mil milton.maciel.ctr@mail.mil.
Premkumar DinadayalaSanofi Pasteur, Marcy-l'Etoile, France.
Kathleen E DoriHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Annette L McVeighHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Yang LiuHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Eileen BarryCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Christen GrasselCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Michael G ProutyEnteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
Geneviève Renauld-MongénieSanofi Pasteur, Marcy-l'Etoile, France.
Stephen J SavarinoEnteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
Henry M. Jackson Foundation · USSanofi (France) · FRUniformed Services University of the Health Sciences · USUniversity of Maryland, Baltimore · USNaval Medical Research Command · US

Funding

Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
NIAID NIH HHS U19 AI109776
6 · The paper itself

Abstract

CS6, a prevalent surface antigen expressed in nearly 20% of clinical enterotoxigenic

Indexed as

AnimalsAntibodies, BacterialAntigens, BacterialEnterotoxigenic Escherichia coliEscherichia coli ProteinsEscherichia coli VaccinesFemaleGene Expression Regulation, BacterialImmunoglobulin GMiceMice, Inbred BALB CProtein SubunitsAntibodies, BacterialAntigens, BacterialCS6 antigen, E coliEscherichia coli ProteinsEscherichia coli VaccinesImmunoglobulin GProtein SubunitsCS6enterotoxigenic Escherichia colimicevaccines

Identifiers

PMID30602504
PMCPMC6386543
OpenAlexW2908505419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.