Evidence map›Paper›PMID 30602500›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2019

Low Expression of the Androgen-Induced Tumor Suppressor Gene

Konrad H Stopsack, Travis Gerke, Svitlana Tyekucheva, Ying Z Mazzu, Gwo-Shu Mary Lee, Goutam Chakraborty, Wassim Abida, Lorelei A Mucci, Philip W Kantoff

Abstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Konrad H StopsackDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-0722-1311
Travis GerkeDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Svitlana TyekuchevaDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-3119-6507
Ying Z MazzuDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Gwo-Shu Mary LeeDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Goutam ChakrabortyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Wassim AbidaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Lorelei A Mucci *Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Philip W Kantoff *Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. kantoff@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tumor and Circulating Markers as Links Between Obesity and Lethal Prostate CanceP50CA090381 · NCI · DANA-FARBER CANCER INSTITUTE · PI KANTOFF, PHILIP W · 2002 to 2017
$36.2M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Physicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7M
Lentivirus Replication Strategy and PathogenesisR01AI136581 · NIAID · EMORY UNIVERSITY · PI Baek Kim · 2018 to 2026
$3.9M
SAMHD1 controls dNTP pool and HIV sensitivity to NRTIsR01GM104198 · NIGMS · UNIVERSITY OF ROCHESTER · PI KIM, BAEK · 2012 to 2018
$2.3M
RANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775k
TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'SR01HL034595 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 1991
–
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA090381NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NCI NIH HHS U01 CA167552NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NIAID NIH HHS R01 AI136581NIGMS NIH HHS R01 GM104198
6 · The paper itself

Abstract

background4%-9% of prostate cancers harbor homozygous deletions of the androgen-induced tumor suppressor gene, promyelocytic leukemia zinc finger (

methodsWe assessed

results

conclusionsLow expression of the tumor suppressor gene IMPACT: Suppression of

Indexed as

AdultAgedAged, 80 and overCell Line, TumorGenes, Tumor SuppressorHumansMaleMiddle AgedPromyelocytic Leukemia Zinc Finger ProteinProstatic NeoplasmsPromyelocytic Leukemia Zinc Finger ProteinZBTB16 protein, human

Identifiers

PMID30602500
PMCPMC6532645

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.