ArticleCirculation research2019
Protein Phosphatase 2A Regulates Cardiac Na
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Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 37 citations in OpenAlex.
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- Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α.npj metabolic health and disease · 2024Article
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- Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias.International journal of molecular sciences · 2022Review
- Calcium/calmodulin-dependent protein kinase II associates with the KFrontiers in neuroanatomy · 2022Article
- Ventricular voltage-gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation.Clinical and translational medicine · 2021Review
- Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel NaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regulatory mechanism of calcium/calmodulin-dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review).Experimental and therapeutic medicine · 2021Review
- Protein Phosphatase 2A Deficiency in Macrophages Increases Foam Cell Formation and Accelerates Atherosclerotic Lesion Development.Frontiers in cardiovascular medicine · 2021Article
- CaMKII in Regulation of Cell Death During Myocardial Reperfusion Injury.Frontiers in molecular biosciences · 2021Review
- The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα-SOD2 pathway.Cell death and differentiation · 2020Article
- CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability.The Journal of biological chemistry · 2020Article
- Late ICirculation. Arrhythmia and electrophysiology · 2020Article
- Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies.Cardiovascular research · 2020Review
- Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia.Heart rhythm · 2020Article
- "Heart Oddity": Intrinsically Reduced Excitability in the Right Ventricle Requires Compensation by Regionally Specific Stress Kinase Function.Frontiers in physiology · 2020Review
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- Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination.Frontiers in pharmacology · 2020Article
- A Novel Gene Signature to Predict Survival Time and Incident Ventricular Arrhythmias in Patients with Dilated Cardiomyopathy.Disease markers · 2020Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Mona El RefaeyFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Hassan MusaFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Nathaniel P MurphyFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Ellen R LubbersFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Michel SkafFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Mei HanFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Omer CavusFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Sara N KoenigFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Michael J WallaceFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Daniel GratzFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Elisa BradleyFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Katherina M AlsinaDepartment of Molecular Physiology and Biophysics (K.M.A.), Baylor College of Medicine, Houston, TX.
Xander H T WehrensCardiovascular Research Institute, Baylor College of Medicine, Houston, TX (X.H.T.W.).
Thomas J HundFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
Peter J MohlerFrom the Ohio State University College of Medicine and Wexner Medical Center, The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, Columbus (M.E.R., H.M., N.P.M., E.R.L., M.S., M.H., O.C., S.N.K., M.J.W., D.G., E.B., T.J.H., P.J.M.).
The Ohio State University Wexner Medical Center · USThe Ohio State University · USBaylor College of Medicine · US
Funding
Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5MDefining novel mechanisms for human arrhythmiaR35HL135754 · NHLBI · OHIO STATE UNIVERSITY · PI MOHLER, PETER J. · 2017 to 2023
$6.0MRole of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitabilityR01HL083422 · NHLBI · VANDERBILT UNIVERSITY · PI MOHLER, PETER J. · 2006 to 2016
$3.8MRegulation of Sarcoplasmic Reticulum Calcium Release in Heart FailureR01HL091947 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2009 to 2019
$3.2MDefining novel mechanisms for regulation of atrial INa and arrhythmiasR01HL134824 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY, MOHLER, PETER J. · 2017 to 2020
$3.0MTraining in Congenital and Acquired Heart DiseaseT32HL098039 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU, MOHLER, PETER J. · 2009 to 2019
$2.5MDetermining the Role of Junctophilin-2 in Cardiac DiseaseR01HL117641 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2014 to 2017
$2.3MEHD proteins in cardiac membrane protein targeting and remodelingR01HL114383 · NHLBI · OHIO STATE UNIVERSITY · PI BOYDEN, PENELOPE ALTMAN, MOHLER, PETER J. · 2013 to 2016
$2.1MDefining the Impact of E-Cigarettes on Cardiac PathophysiologyR01HL139348 · NHLBI · OHIO STATE UNIVERSITY · PI WOLD, LOREN EUGENE · 2017 to 2020
$1.9MCaMKII-dependent regulation of cardiac excitabilityR01HL114893 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2012 to 2016
$1.9MSpectrin-based regulation of cardiac remodeling and heart failureR01HL135096 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2017 to 2020
$1.6MDefining the Role of Alpha II Spectrin in Cardiac Function and DiseaseF30HL137331 · NHLBI · OHIO STATE UNIVERSITY · PI LUBBERS, ELLEN · 2017 to 2020
$176kNHLBI NIH HHS F30 HL137331NHLBI NIH HHS R01 HL083422NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL091947NHLBI NIH HHS R01 HL114383NHLBI NIH HHS R01 HL114893NHLBI NIH HHS R01 HL117641NHLBI NIH HHS R01 HL134824NHLBI NIH HHS R01 HL135096NHLBI NIH HHS R01 HL139348NHLBI NIH HHS R35 HL135754NHLBI NIH HHS T32 HL098039
Abstract
rationaleVoltage-gated Na
objectiveTo define phosphatase pathways that regulate I METHODS AND
resultsA mouse model lacking a key regulatory subunit (B56α) of the PP (protein phosphatase) 2A holoenzyme displayed aberrant action potentials after adrenergic stimulation. Unbiased computational modeling of B56α KO (knockout) mouse myocyte action potentials revealed an unexpected role of PP2A in I
conclusionsPP2A regulates Na
Indexed as
Heart RateIon Channel GatingAction PotentialsAdrenergic beta-AgonistsAnimalsArrhythmias, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2FemaleGenetic Predisposition to DiseaseHumansMaleMice, Inbred C57BLMice, KnockoutMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelPhenotypeAdrenergic beta-AgonistsCalcium-Calmodulin-Dependent Protein Kinase Type 2NAV1.5 Voltage-Gated Sodium ChannelPpp2r5a protein, mouseProtein Phosphatase 2Scn5a protein, mouseankyrinsarrhythmias, cardiaccalcium-calmodulin-dependent protein kinase type 2phosphorylationphysiology
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