ArticleEmerging infectious diseases2019
Increased Risk for Invasive Group A Streptococcus Disease for Household Contacts of Scarlet Fever Cases, England, 2011-2016.
Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review of Household Transmission of Strep A: A Potential Site for Prevention That Has Eluded Attention.The Journal of infectious diseases · 2024Pooled it
- Time to negative throat culture following initiation of antibiotics for pharyngeal group AEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Pooled it
- Current Clinical Practice on the Management of Invasive Streptococcus Pyogenes Infections in Children: A Survey-Based Study.Antibiotics (Basel, Switzerland) · 2025Article
- Analysis ofmBio · 2025Article
- Risk factors for invasive group A streptococcal infection in children aged 6 months to 5 years: a case-control study, the Netherlands, February-May 2023.Epidemiology and infection · 2025Article
- The intricate pathogenicity of Group AVirulence · 2024Review
- Nationwide upsurge in invasive disease in the context of longitudinal surveillance of carriage and invasiveJournal of clinical microbiology · 2024Article
- Pathogenesis, epidemiology and control of Group A Streptococcus infection.Nature reviews. Microbiology · 2023Review
- Toxic Streptococcal Infection in Children: Report on Two Cases with Uncharacteristic Course of Scarlet Fever.Children (Basel, Switzerland) · 2023Article
- Increase in invasive group A streptococcal infection notifications, England, 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- The dynamics of scarlet fever in The Netherlands, 1906-1920: a historical analysis.Royal Society open science · 2022Article
- Article
- Clinical management and impact of scarlet fever in the modern era: findings from a cross-sectional study of cases in London, 2018-2019.BMJ open · 2021Article
- A Review ofPathogens (Basel, Switzerland) · 2021Review
- Out-of-season increase of puerperal fever with group AEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Analysis of Epidemiological Characteristics of Scarlet Fever in Zhejiang Province, China, 2004-2018.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The incidence of scarlet fever in England and Wales is at its highest in 50 years. We estimated secondary household risk for invasive group A Streptococcus (iGAS) disease within 60 days after onset of scarlet fever. Reports of scarlet fever in England during 2011-2016 were matched by residential address to persons with laboratory-confirmed iGAS infections. We identified 11 iGAS cases in ≈189,684 household contacts and a 60-day incidence rate of 35.3 cases/100,000 person-years, which was 12.2-fold higher than the background rate (2.89). Infants and contacts >75 years of age were at highest risk. Three cases were fatal; sepsis and cellulitis were the most common manifestations. Typing for 6 iGAS cases identified emm 1.0 (n = 4), emm 4.0 (n = 1), and emm 12.0 (n = 1). Although absolute risk in household contacts was low, clinicians assessing household contacts should be aware of the risk to expedite diagnosis and initiate life-saving treatment.
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Registered trials
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