Evidence map›Paper›PMID 30602059›Full record

ReviewCancer2019

The role of neuro-immune interactions in cancer-related fatigue: Biobehavioral risk factors and mechanisms.

Julienne E Bower

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  4. Pooled it
  5. Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Pooled it
  6. Pooled it
  7. Severe fatigue after treatment for childhood cancer.The Cochrane database of systematic reviews · 2020
    Pooled it
  8. Trial
  9. Trial
  10. Trial
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  12. Effectiveness of mat pilates on fatigue in women with breast cancer submitted to adjuvant radiotherapy: randomized controlled clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
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  15. Relationship between circadian activity rhythms and fatigue in hospitalized children with CNS cancers receiving high-dose chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Trial
  16. Trial
  17. The influence of virtual reality on anxiety and pain in breast cancer patients: A systematic review.Technical innovations & patient support in radiation oncology · 2026
    Review
  18. Article
  19. From traditional warming and tonifying to psychoneuroimmunology: theoretical reconstruction and clinical application of moxibustion for cancer-related fatigue.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Julienne E BowerDepartment of Psychology, Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California.

Funding

A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer SurvivorsR01CA200977 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E, GANZ, PATRICIA A. · 2016 to 2020
$3.2M
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patientsR01CA160427 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2012 to 2016
$3.2M
NCI NIH HHS R01 CA160427NCI NIH HHS R01 CA200977
6 · The paper itself

Abstract

Fatigue is a common and distressing symptom in both patients with cancer and cancer survivors. There is substantial variation in the severity and persistence of cancer-related fatigue that may be driven by individual differences in host factors, including characteristics that predate the cancer experience as well as responses to cancer and its treatment. This review examines biobehavioral risk factors linked to fatigue and the mechanisms through which they influence fatigue across the cancer continuum, with a focus on neuro-immune processes. Among psychosocial risk factors, childhood adversity is a strong and consistent predictor of cancer-related fatigue; other risk factors include history of depression, catastrophizing, lack of physical activity, and sleep disturbance, with compelling preliminary evidence for loneliness and trait anxiety. Among biologic systems, initial work suggests that alterations in immune, neuroendocrine, and neural processes are associated with fatigue. The identification of key risk factors and underlying mechanisms is critical for the development and deployment of targeted interventions to reduce the burden of fatigue in the growing population of cancer survivors. Given the multidimensional nature of fatigue, interventions that influence multiple systems may be most effective.

Indexed as

AnxietyBehaviorCancer SurvivorsDepressionFatigueHumansNeoplasmsNeuroimmunomodulationQuality of LifeRisk Factorsbiobehavioralfatigueinflammationneuro-immunepsychosocial

Identifiers

PMID30602059
PMCPMC6502236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.