Evidence map›Paper›PMID 30601999›Full record

Trial reportInflammatory bowel diseases2019

Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza and Upper Respiratory Infection in Patients With Inflammatory Bowel Disease.

Seiji Arihiro, Akio Nakashima, Mika Matsuoka, Satoshi Suto, Kan Uchiyama, Tomohiro Kato, Jimi Mitobe, Nobuhiko Komoike, Munenori Itagaki, Yoshinari Miyakawa and 6 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Inflammatory bowel diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 8 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 8 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
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  3. Vitamin D for the treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2023
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  9. Trial
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  11. Article
  12. Article
  13. The Role of Vitamin D in Gastrointestinal Homeostasis and Gut Inflammation.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Seiji ArihiroDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Katsushika Medical Center,Tokyo, Japan.
Akio NakashimaDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Mika MatsuokaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Satoshi SutoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Katsushika Medical Center,Tokyo, Japan.
Kan UchiyamaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, Chiba, Japan.
Tomohiro KatoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Jimi MitobeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Nobuhiko KomoikeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Munenori ItagakiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Katsushika Medical Center,Tokyo, Japan.
Yoshinari MiyakawaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Daisan Hospital, Tokyo, Japan.
Shigeo KoidoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, Chiba, Japan.
Atsushi HokariDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Katsushika Medical Center,Tokyo, Japan.
Masayuki SarutaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Hisao TajiriDepartment of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo, Japan.
Tomokazu MatsuuraDepartment of Internal Medicine, Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Mitsuyoshi UrashimaDivision of Molecular Epidemiology, The Jikei University School of Medicine, Tokyo, Japan.
Jikei University School of Medicine · JPKatsushika Medical Center · JPJikei University Kashiwa hospital · JPThe Jikei University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe evaluated whether oral vitamin D supplementation during the winter and early spring reduces the incidence of influenza and upper respiratory infections in patients with inflammatory bowel disease (IBD).

methodsA randomized, double-blind, controlled trial was conducted to compare the effects of vitamin D supplementation (500 IU/day) and a placebo. The primary outcome was the incidence of influenza; the secondary outcome was the incidence of upper respiratory infection. Prespecified subgroup analyses were performed according to 25-hydroxyvitamin D (25-OHD) levels (low <20 ng/mL or high ≥20 ng/mL) and whether ulcerative colitis (UC) or Crohn's disease (CD) was present. We also used the Lichtiger clinical activity index for patients with UC and the Crohn's Disease Activity Index (CDAI) for patients with CD before and after interventions.

resultsWe included 223 patients with IBD and randomized them into 2 groups: vitamin D supplementation (n = 108) and placebo (n = 115). The incidence of influenza did not differ between the groups. However, the incidence of upper respiratory infection was significantly lower in the vitamin D group (relative risk [RR], 0.59; 95% confidence interval (CI), 0.35-0.98; P = 0.042). This effect was enhanced in the low 25-OHD level subgroup (RR, 0.36; 95% CI, 0.14-0.90; P = 0.02). With respect to adverse events, the Lichtiger clinical activity index score was significantly worse in the vitamin D group (P = 0.002) and remained significant only in the high 25-OHD level subgroup.

conclusionsVitamin D supplementation may have a preventative effect against upper respiratory infection in patients with IBD but may worsen the symptoms of UC.

Indexed as

Dietary SupplementsAdultDouble-Blind MethodFemaleFollow-Up StudiesHumansIncidenceInflammatory Bowel DiseasesInfluenza A virusInfluenza, HumanJapanMaleMiddle AgedPrognosisRespiratory Tract InfectionsSeasonsVitamin DVitaminsCrohn’s diseaseulcerative colitisvitamin D3 supplementation

Identifiers

PMID30601999
PMCPMC6499936
OpenAlexW2907328358

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.