ArticleInvestigative ophthalmology & visual science2019
Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- In Vivo Biomechanical Characteristics of Human Corneas With Phase-Decorrelation OCT.Investigative ophthalmology & visual science · 2026Article
- Riboflavin-UV crosslinking of the cornea: Wound healing and biomechanics.Experimental eye research · 2025Review
- Corneal Biomechanical Changes Induced by Chronic Elevated Intraocular Pressure: Implications for Glaucoma Pathogenesis and Management.Journal of ophthalmology · 2025Review
- Compressed intracellular motility via non-uniform temporal sampling in dynamic optical coherence tomography.Journal of biomedical optics · 2024Article
- Pediatric keratoconus epidemiology: a systematic scoping review.International ophthalmology · 2024Article
- Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift.Eye and vision (London, England) · 2023Review
- Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography.Biomedical optics express · 2023Article
- Article
- Phase-Decorrelation Optical Coherence Tomography Measurement of Cold-Induced Nuclear Cataract.Translational vision science & technology · 2023Article
- Review
- Adverse events after riboflavin/UV-A corneal cross-linking: a literature review.International ophthalmology · 2022Review
- Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021Review
- Depth-resolved Corneal Biomechanical Changes Measured Via Optical Coherence Elastography Following Corneal Crosslinking.Translational vision science & technology · 2021Article
- Corneal Crosslinking in Refractive Corrections.Translational vision science & technology · 2021Article
- Corneal biomechanics: Measurement and structural correlations.Experimental eye research · 2021Review
- Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking.Investigative ophthalmology & visual science · 2020Article
- Corneal Hydration Control during Ex Vivo Experimentation Using Poloxamers.Current eye research · 2020Article
- A Mesh-Free Approach to Incorporate Complex Anisotropic and Heterogeneous Material Properties into Eye-Specific Finite Element Models.Computer methods in applied mechanics and engineering · 2020Article
- Dynamic imaging and quantification of subcellular motion with eigen-decomposition optical coherence tomography-based variance analysis.Journal of biophotonics · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Purpose: There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanical assessment have various drawbacks: dependence on IOP, long acquisition times, or limited resolution. Here, we present a method that may avoid these limitations by using optical coherence tomography (OCT) to detect the endogenous random motion within the cornea, which can be associated with stromal crosslinking. Methods: Phase-decorrelation OCT (PhD-OCT), based in the theory of dynamic light scattering, is a method to spatially resolve endogenous random motion by calculating the decorrelation rate, Γ, of the temporally evolving complex-valued OCT signal. PhD-OCT images of ex vivo porcine globes were recorded during CXL and control protocols. In addition, human patients were imaged with PhD-OCT using a clinical OCT system. Results: In both the porcine cornea and the human cornea, crosslinking results in a reduction of Γ (P < 0.0001), indicating more crosslinks. This effect was repeatable in ex vivo porcine corneas (change in average Γ = -41.55 ± 9.64%, n = 5) and not seen after sham treatments (change in average Γ = 2.83 ± 12.56%, n = 5). No dependence of PhD-OCT on IOP was found, and correctable effects were caused by variations in signal-to-noise ratio, hydration, and motion. Conclusions: PhD-OCT may be a useful and readily translatable tool for investigating biomechanical properties of the cornea and for enhancing the diagnosis and treatment of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.