ArticleMolecular biology of the cell2019
salto/CG13164 is required for sperm head morphogenesis in Drosophila.
Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- A comparison of spermatogenesis between flies and men-conserved processes of male gamete production.Human reproduction update · 2025Review
- Molecular models of the sperm head-tail coupling apparatus.Journal of cell science · 2025Review
- An orphan gene is essential for efficient sperm entry into eggs in Drosophila melanogaster.Genetics · 2025Article
- A deficiency screen identifies genomic regions critical for sperm head-tail connection.G3 (Bethesda, Md.) · 2025Article
- Cytoplasmic incompatibility factor proteins fromProceedings. Biological sciences · 2025Article
- An orphan gene is essential for efficient sperm entry into eggs inbioRxiv : the preprint server for biology · 2024Article
- The proximal centriole-like structure maintains nucleus-centriole architecture in sperm.Journal of cell science · 2024Article
- A deficiency screen identifies genomic regions critical for sperm head-tail connection.bioRxiv : the preprint server for biology · 2024Article
- A type VI secretion system effector TseG of Pantoea ananatis is involved in virulence and antibacterial activity.Molecular plant pathology · 2024Article
- Cep104 is a component of the centriole distal tip complex that regulates centriole growth and contributes to Drosophila spermiogenesis.Current biology : CB · 2023Article
- The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia.Scientific reports · 2022Article
- Mutation inFrontiers in cell and developmental biology · 2022Article
- Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice.Autophagy · 2021Article
- The Microtubule Cytoskeleton during the EarlyCells · 2020Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Producing mature spermatozoa is essential for sexual reproduction in metazoans. Spermiogenesis involves dramatic cell morphological changes going from sperm tail elongation and nuclear reshaping to cell membrane remodeling during sperm individualization and release. The sperm manchette plays a critical scaffolding function during nuclear remodeling by linking the nuclear lamina to the cytoskeleton. Here, we describe the role of an uncharacterized protein in Drosophila, salto/CG13164, involved in nuclear shaping and spermatid individualization. Salto has dynamic localization during spermatid differentiation, being progressively relocated from the sperm-nuclear dense body, which is equivalent to the mammalian sperm manchette, to the centriolar adjunct and acrosomal cap during spermiogenesis. salto-null male flies are sterile and exhibit complete spermatid individualization defects. salto-deficient spermatids show coiled spermatid nuclei at late maturation stages and stalled individualization complexes. Our work sheds light on a novel component involved in cytoskeleton-based cell-morphological changes during spermiogenesis.
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