Evidence map›Paper›PMID 30601682›Full record

ReviewAnnual review of biochemistry2019

Mechanism and Regulation of Centriole and Cilium Biogenesis.

David K Breslow, Andrew J Holland

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 293 citations in OpenAlex.

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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David K BreslowDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA; email: david.breslow@yale.edu.
Andrew J HollandDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; email: aholland@jhmi.edu.
Johns Hopkins University · USYale University · US

Funding

Centrosome biogenesis and copy number controlR01GM114119 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CORMACK, BRENDAN · 2015 to 2023
$3.3M
Ciliary control of Gli protein activity in Hedgehog pathway signalingR00HD082280 · NICHD · YALE UNIVERSITY · PI BRESLOW, DAVID KING · 2017 to 2019
$731k
NICHD NIH HHS R00 HD082280NIGMS NIH HHS R01 GM114119
6 · The paper itself

Abstract

The centriole is an ancient microtubule-based organelle with a conserved nine-fold symmetry. Centrioles form the core of centrosomes, which organize the interphase microtubule cytoskeleton of most animal cells and form the poles of the mitotic spindle. Centrioles can also be modified to form basal bodies, which template the formation of cilia and play central roles in cellular signaling, fluid movement, and locomotion. In this review, we discuss developments in our understanding of the biogenesis of centrioles and cilia and the regulatory controls that govern their structure and number. We also discuss how defects in these processes contribute to a spectrum of human diseases and how new technologies have expanded our understanding of centriole and cilium biology, revealing exciting avenues for future exploration.

Indexed as

Organelle BiogenesisAnimalsCell CycleCentriolesCiliaCiliopathiesEukaryotaHumansMitosisSignal Transductioncell cyclecentriolecentrosomeciliaciliopathymitosis

Identifiers

PMID30601682
PMCPMC6588485
OpenAlexW2908004295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.