Evidence map›Paper›PMID 30601679›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Receptor selectivity between the G proteins Gα

Amanda E Mackenzie, Tezz Quon, Li-Chiung Lin, Alexander S Hauser, Laura Jenkins, Asuka Inoue, Andrew B Tobin, David E Gloriam, Brian D Hudson, Graeme Milligan

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Genetic variants of accessory proteins and G proteins in human genetic disease.Critical reviews in clinical laboratory sciences · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Identification of GαScientific reports · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. GαFrontiers in cell and developmental biology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Amanda E MackenzieCentre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Tezz QuonCentre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Li-Chiung LinCentre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Alexander S HauserDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; and.
Laura JenkinsCentre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Andrew B TobinCentre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
David E GloriamDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; and.
Brian D HudsonCentre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Graeme MilliganCentre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
University of Glasgow · GBUniversity of Copenhagen · DKTohoku University · JP

Funding

Medical Research Council MC_UP_A600_1110Medical Research Council MR/P019366/1
6 · The paper itself

Abstract

Despite recent advances in structural definition of GPCR-G protein complexes, the basis of receptor selectivity between G proteins remains unclear. The Gα

Indexed as

beta-ArrestinsCell LineComputational BiologyGTP-Binding Protein alpha Subunits, G12-G13GTP-Binding Protein alpha Subunits, Gq-G11HumansIsoleucineKineticsLeucineLuminescent MeasurementsProtein BindingReceptors, G-Protein-CoupledTransforming Growth Factor alphabeta-ArrestinsGPR35 protein, humanGTP-Binding Protein alpha Subunits, G12-G13GTP-Binding Protein alpha Subunits, Gq-G11IsoleucineLeucineReceptors, G-Protein-CoupledTransforming Growth Factor alphagenome editingGPCRGPR35G protein barcode

Identifiers

PMID30601679
PMCPMC6436656
OpenAlexW2906807123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.