ArticleNano letters2019
Wavelet Denoising of High-Bandwidth Nanopore and Ion-Channel Signals.
Article in Nano letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Addressing the Challenges of Solid-State Nanopores: Strategies for Performance Enhancement.International journal of molecular sciences · 2026Review
- The evolution of nanopore measurements: from biological out-of-plane pores to plastic in-plane pores.Lab on a chip · 2026Review
- Single-Molecule Biodosimetry.Analytical chemistry · 2025Article
- Enhanced Discriminability of Viral Vectors in Viscous Nanopores.Small methods · 2025Article
- A Robust Parallel Computing Data Extraction Framework for Nanopore Experiments.Small methods · 2024Article
- Machine learning empowered next generation DNA sequencing: perspective and prospectus.Chemical science · 2024Review
- Variational Mode Decomposition for Raman Spectral Denoising.Molecules (Basel, Switzerland) · 2023Article
- Nanopore Detection Using Supercharged Polypeptide Molecular Carriers.Journal of the American Chemical Society · 2023Article
- Article
- Environmental noise reduction for tunable resistive pulse sensing of extracellular vesicles.Sensors and actuators. A, Physical · 2022Article
- A Guide to Signal Processing Algorithms for Nanopore Sensors.ACS sensors · 2021Article
- Rational ion transport management mediated through membrane structures.Exploration (Beijing, China) · 2021Review
- Article
- The OpenPicoAmp-100k: an open-source high-performance amplifier for single channel recording in planar lipid bilayers.Pflugers Archiv : European journal of physiology · 2019Article
- Single-Stranded DNA Translocation Recordings through Solid-State Nanopores on Glass Chips at 10 MHz Measurement Bandwidth.ACS nano · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Recent work has pushed the noise-limited bandwidths of solid-state nanopore conductance recordings to more than 5 MHz and of ion channel conductance recordings to more than 500 kHz through the use of integrated complementary metal-oxide-semiconductor (CMOS) integrated circuits. Despite the spectral spread of the pulse-like signals that characterize these recordings when a sinusoidal basis is employed, Bessel filters are commonly used to denoise these signals to acceptable signal-to-noise ratios (SNRs) at the cost of losing many of the faster temporal features. Here, we report improvements to the SNR that can be achieved using wavelet denoising instead of Bessel filtering. When combined with state-of-the-art high-bandwidth CMOS recording instrumentation, we can reduce baseline noise levels by over a factor of 4 compared to a 2.5 MHz Bessel filter while retaining transient properties in the signal comparable to this filter bandwidth. Similarly, for ion-channel recordings, we achieve a temporal response better than a 100 kHz Bessel filter with a noise level comparable to that achievable with a 25 kHz Bessel filter. Improvements in SNR can be used to achieve robust statistical analyses of these recordings, which may provide important insights into nanopore translocation dynamics and mechanisms of ion-channel function.
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Registered trials
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