Evidence map›Paper›PMID 30601598›Full record

ArticleJournal of the International AIDS Society2018

Molecular epidemiology of a primarily MSM acute HIV-1 cohort in Bangkok, Thailand and connections within networks of transmission in Asia.

David Chang, Eric Sanders-Buell, Meera Bose, Anne Marie O'Sullivan, Phuc Pham, Eugene Kroon, Donn J Colby, Rujipas Sirijatuphat, Erik Billings, Suteeraporn Pinyakorn and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International AIDS Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

David ChangUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Eric Sanders-BuellUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Meera BoseUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Anne Marie O'SullivanUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Phuc PhamUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Eugene KroonSEARCH, Bangkok, Thailand.
Donn J ColbySEARCH, Bangkok, Thailand.
Rujipas SirijatuphatUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Erik BillingsUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Suteeraporn PinyakornUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Nitiya ChomcheySEARCH, Bangkok, Thailand.
Wiriya RutvisuttinuntDepartment of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Gustavo KijakUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Mark de SouzaThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Jean-Louis ExclerUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Praphan PhanuphakThe Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Nittaya PhanuphakThe Thai Red Cross AIDS Research Centre, Bangkok, Thailand.ORCID 0000-0002-0036-3165
Robert J O'ConnellUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Jerome H KimUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Merlin L RobbUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Nelson L MichaelUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Jintanat AnanworanichUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0003-1369-3224
Sodsai TovanabutraUnited States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0002-5946-4227
RV254/SEARCH 010 Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThailand plays a substantial role in global HIV-1 transmission of CRF01_AE. Worldwide, men who have sex with men (MSM) are at elevated risk for HIV-1 infection. Hence, understanding HIV-1 diversity in a primarily Thai MSM cohort with acute infection, and its connections to the broader HIV-1 transmission network in Asia is crucial for research and development of HIV-1 vaccines, treatment and cure.

methodsSubtypes and diversity of infecting viruses from individuals sampled from 2009 to 2015 within the RV254/SEARCH 010 cohort were assessed by multiregion hybridization assay (MHAbce), multiregion subtype-specific PCR assay (MSSPbce) and full-length single-genome sequencing (SGS). Phylogenetic analysis was performed by maximum likelihood. Pairwise genetic distances of envelope gp160 sequences obtained from the cohort and from Asia (Los Alamos National Laboratory HIV Database) were calculated to identify potential transmission networks.

resultsMHAbce/MSSPbce results identified 81.6% CRF01_AE infecting strains in RV254. CRF01_AE/B recombinants and subtype B were found at 7.3% and 2.8% respectively. Western subtype B strains outnumbered Thai B' strains. Phylogenetic analysis revealed one C, one CRF01_AE/CRF02_AG recombinant and one CRF01_AE/B/C recombinant. Asian network analysis identified one hundred and twenty-three clusters, including five clusters of RV254 participants. None of the RV254 sequences clustered with non-RV254 sequences. The largest international cluster involved 15 CRF01_AE strains from China and Vietnam. The remaining clusters were mostly intracountry connections, of which 31.7% included Thai nodes and 43.1% included Chinese nodes.

conclusionWhile the majority of strains in Thailand are CRF01_AE and subtype B, emergence of unique recombinant forms (URFs) are found in a moderate fraction of new HIV-1 infections. Approaches to vaccine design and immunotherapeutics will need to monitor and consider the expanding proportion of recombinants and the increasing genetic diversity in the region. Identified HIV-1 transmission networks indicate ongoing spread of HIV-1 among MSM. As HIV-1 epidemics continue to expand in other Asian countries, transmission network analyses can inform strategies for prevention, intervention, treatment and cure.

Indexed as

Homosexuality, MaleMolecular EpidemiologyCohort StudiesGenetic VariationHIV-1HIV InfectionsHIV SeropositivityHumansLongitudinal StudiesMalePhylogenyProspective StudiesThailandacute infectionAsia transmission networkHIV-1 molecular epidemiologyinterventionMSMrecombinantsThailandvaccine

Identifiers

PMID30601598
PMCPMC6282942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.