ArticleAIDS (London, England)2019
Associations between baseline biomarkers and lung function in HIV-positive individuals.
Article in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Serum bilirubin and chronic obstructive pulmonary disease (COPD): a systematic review.BMC pulmonary medicine · 2021Pooled it
- Biomarkers of Inflammation and Longitudinal Evaluation of Lung Function, Physical Activity, and Grip Strength: A Secondary Analysis in the CASCADE Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Pneumoproteins and biomarkers of inflammation and coagulation do not predict rapid lung function decline in people living with HIV.Scientific reports · 2023Article
- Lung proteome and metabolome endotype in HIV-associated obstructive lung disease.ERJ open research · 2023Article
- Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort.Annals of the American Thoracic Society · 2022Article
- Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study.International journal of chronic obstructive pulmonary disease · 2022Observational
- Association Between Serum Total Bilirubin and COPD: Results from a Cross-Sectional Study and a Bidirectional Mendelian Randomization Analysis.Clinical epidemiology · 2022Article
- Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.AIDS (London, England) · 2021Observational
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 5 countries.
Funding
Abstract
objectiveThe aim of this study was to analyse the association of baseline biomarker data with cross-sectional lung function and subsequent decline in lung function in HIV-positive persons.
designLung function was modelled in all START pulmonary substudy participants who had baseline biomarker data and good-quality spirometry. In longitudinal analyses, we restricted to those participants with at least one good-quality follow-up spirometry test.
methodsWe performed linear regression of baseline forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC and their longitudinal slopes on log2-transformed baseline biomarkers with adjustment for age, sex, race, region, smoking status, baseline CD4+ T-cell counts and baseline HIV-RNA. Biomarkers included D-dimer, high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-27, serum amyloid A, soluble intercellular adhesion molecule (sICAM)-1, soluble vascular cell adhesion molecule (sVCAM)-1, albumin and total bilirubin.
resultsAmong 903 included participants, baseline median age was 36 years, CD4+ cell count was 647 cells/μl, and 28.5% were current smokers. In adjusted analyses, elevated markers of systemic inflammation (hsCRP, IL-6 and serum amyloid A) were associated with lower baseline FEV1 and FVC. Elevated D-dimer and IL-6 were associated with worse airflow obstruction (lower FEV1/FVC). Despite these cross-sectional associations at baseline, no associations were found between baseline biomarkers and subsequent longitudinal lung function decline over a median follow-up time of 3.9 years (3293 spirometry-years of follow-up).
conclusionCommonly available biomarkers, in particular markers of systemic inflammation, are associated with worse cross-sectional lung function, but do not associate with subsequent lung function decline among HIV-positive persons with early HIV infection and baseline CD4 T-cell counts more than 500 cells/μl.
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